Port stains (PWS) are not only a concern for cosmetics, but also a congenital disease characterized by abnormal capillary swelling, affecting a small number of newborns. As an age, these markers usually become more pronounced, resistant to treatment and may lead to hypertrophy. In addition to physical performance, PW also significantly affects individual social interactions and produces mental health from an early age. Traditional treatments are often insufficient, especially for deeper or more stubborn lesions.
The collaborative effort led by Professor Xueding Wang and his team, including Mingyang Wang, Wei Zhang, Dr. Jeffrey Orringer, and Dr. Yannis Paulus from the University, is a collaborative effort for new treatments for Port-Wine stains and vascular malformations. Michigan collaborates with Rohit Singh of Photosonox LLC and Dr. Xinmai Yang of the University of Kansas. The team introduced photo-mediated ultrasound therapy (PUT), an innovative approach that fuses low-energy laser pulses with ultrasound bursts, providing patients with selective and minimally invasive options, as published in JID Innovation Research described.
The PUT system uniquely integrates a focus ultrasonic (FUS) setup with a nanosecond pulsed laser source. The system ensures precise control of the treatment area. This accuracy is achieved through spatial alignment and time synchronization of ultrasonic bursts and laser pulses, thereby improving the therapeutic efficiency of the method.
Professor Wang stressed the importance of PUT, describing it as a “highly selective antivascular technology based on cavitation.” “The findings from this study show that using laser flux levels is significantly lower than those treated with conventional lasers, which can effectively and safely remove hypervascular dermal capillaries, thus providing a safer alternative to clinical management plan.”
Compared with traditional PDL therapy, Professor Wang emphasized how to circumvent the limitations of laser therapy when addressing minimized thermal effects. Using low laser frequencies next to ultrasound bursts greatly reduces adverse thermal damage, which marks it as the best choice for treating vascular lesions.
Comprehensive histological and immunohistochemical analysis was used to confirm selective damage to vascular tissue while preserving the surrounding structure. A detailed examination of chicken samples stained with various markers was clearly evaluated for the efficacy and specificity of the treatment.
Professor Wang further explained: “The additional immunohistochemical evaluation shows that the required vascular damage caused by POT treatment. It is worth noting that collagen in the treated area retains structure and morphology similar to that of the untreated area, indicating that there is no Colonial damage. “This study marks a significant advance in the clinical management of vascular skin diseases, providing more effective and safer treatment options for people with PWS and similar diseases. The collaborative efforts led by Professor Wang and his team are committed to providing improved quality of life for many.
Journal Reference
Mingyang Wang, Rohit Singh, Wei Zhang, Jeffrey S. Orringer, Yannis M. Paulus, Xinmai Yang, and Xueding Wang. “Hypervascularization of skin using light-mediated ultrasound therapy.” Jid Innovations, 2023.
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