The role of decomposition biological gender in the progress of COVID-19 diseases and related cytokine storms

Researchers from the University of California, researcher at the University of San Francisco, Dr. Aditi Bhargava and Johannes KNApp of Aseesa Inc., reveal the severity of the important insights of how biological gender becomes an important variable of the immune system to regulate the important variable of SARS-COV-2. Their research was published in the magazine magazine and re -analyzed data from early patients from 199 patients to understand the factors that caused the disease to become serious, especially how the immune system sometimes disrupted and the differences between men and women. Affect the results of the disease.

As early as 2020, as the world faced on the 19th, the huge challenge of COVID-19 was obvious that the virus did not affect everyone in the same way. Among the many factors affecting patients, gender differences stand out, and men often experience worse results than women. Dr. Bhargava and Dr. KnApp have discussed these differences by checking the immune response of patients with intensives for the intensive care unit (ICU) due to COVID-19. Their discovery may lead to better treatment and management of diseases.

The study was published in cells and emphasized the key role of multi-active immune response in COVID-19 in COVID-19, which is seriously ill. Researchers have found that compared with women, men in ICU have shown greater changes in the immune system and overall health, and the obvious part of their analysis shows obvious differences between gender. One of the most striking discoveries is the higher level of certain immune cells, such as GZB+ CD8+ T cells generated by granulzyrase -b, subsets of CD8TEMRA and cytokines, such as Interfereon-γ (IFN-) (IFN- γ), ILLUKIN-2 (IL)-2 and IL-1α in patients who did not survive. The number of immune cells and cytokine levels is not obvious among patients with recovery. When comparing men and women, this difference is particularly obvious, emphasizing the complex interaction between biological gender, immune response, and the severity of the disease ending.

Dr. Bhargava pointed out: “Our analysis shows that the importance of biological gender in shaping the immune response to COVID-19, especially in severe cases of intensive care. Understanding these differences is to develop a tailor-made for men and women. The key to more effective treatment and/or nursing.

In addition, the study found that obesity is the most important risk factor that leads to the common 19 cases of death, and even more important than other previous diseases (such as immunosuppressing, chronic heart or lung disease). The result of obese patients is the worst, and researchers believe that this may be due to the stronger response of these people. Although the early use of hydroxyl chloride, RemDesivir and Tocilizumab were used, these therapies did not effectively reduce the level of IL-6. The level of IL-6 was a serious immune response, called COVID-19 patients with cytokine storms.

The researchers also compared the immune characteristics of COVID-19 patients in ICU and hospitalized non-ICU patients, and found that the number of immune cells in patients in ICU was significantly less than several different immune cell subtypes, not in intensive care. This includes a significant reduction in certain types of T cells and the increase in protein such as IL-6 and vascular endothelial growth factor A, which indicates that the immunity and microvascular system of severe patients are more disordered. However, the study also found that some therapies, especially corticosteroids, did not significantly change the immune response of patients with severe illnesses, which indicates that different treatment methods may be required.

The work of Dr. Bhargava and KNAPP is the appeal of the scientific community. It is necessary to pay more attention to the gender differences in clinical research, especially in diseases such as COVID-19, the immune system plays a vital effect. As Dr. Bhargava commented: “By understanding and understanding these differences, we can better tailor the treatment method and improve everyone’s results, regardless of the gender of biology.” Failure to study gender differences, because Yale University influence Study the expected data that does not specify gender. Gender and biological gender are different and should not be confused.

This study is an important step in our understanding of Covid-19, and emphasizes the importance of comprehensive analysis in understanding and treating complex diseases.

Journal reference

Bhargava, A. And JD KNAPP (2023). “Immune disorders and gender differences: The similarity of early research on Covid-19 missed the opportunity to have real impact.” Cell, 12 (22), 2591. https://doi.org/10.3390/cells12222591

Other reference

Lucas, C. Wong, P. ; Klein, J. ; Castro, TBR; Silva, J. ; Sundaram, M. ; MK Ellingson; Mao, T. ; Oh, Jie; Israel, B. wait. Vertical analysis shows that in severe COVID-19, immunological fires. nature 2020,,,,, 584463–469.

Takahashi, T. Mk ellingson; wong, p. ; Israel, B. Lucas, C. Klein, J. ; Silva, J. ; MAO, T. ; Oh, Jie; Tokuyama, M. ;wait. Gender differences based on the ending of COVID-19 disease ending. nature 2020,,,,, 588315–320

Bhargava, A. ; Arnold, Associated Press; Bangasser, DA; Danon, kilometers; Gupta Hilliaard Krause, LM; Mayer, EA; M. McCarthy; WL Miller; Raznahan, A. ;wait. Biological variables as a basis and clinical research: statement of endocrine social sciences. Inner master. Revised version2021,,,,, 42219–258.

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