Communication between cells is essential for the normal operation of the human body, and a way of this occurring is through a small channel called a gap connection. These channels are regulated by two different mechanisms: a chemical gate and a gate that is sensitive to voltage. Professor Camillo PERACCHIA at the University of Rochester at the University of Rochester recently published a study in the “International Molecular Science Magazine” to discuss how these mechanisms control the flow of information between cells, thereby providing new insights for this complex process. Essence
Cell use gap connects important signals and molecules with each other. These channels are particularly responded to changes in intracellular calcium levels and the voltage of the entire cell membrane. When conditions change, these factors can cause channels to open or turn off through chemical gate or sensitive grille. Professor PERACCHIA’s research shows that the chemical door is controlled by a protein called calcium protein, which plays a vital role in many cell activity. On the other hand, the grille that is sensitive to voltage is composed of a part of the protein called the NH2-terminal domain.
As Professor Peracchia explained: “The chemical doors are closed under the increase in calcium levels inside the cells and the entire cell membrane is closed.” This means that the chemical gate response Essence At the same time, the effect of sensitive doors of voltage is faster, but it has not fully closed the channel, and the degree of opening of the channel has been slightly adjusted. The study also shows that these doorsal reactions may change according to the specific types of the connected protein involved, showing the complex balance between chemistry and electrical signals when controlling these channels.
Professor PERACCHIA further emphasizes: “Cynexial acidification changes the sensitivity of the fast voltage sensitive door in the opposite way: in some cases, it increases the sensitivity of the door and reduces it in other circumstances.” The dual -door control system can ensure that it can ensure that Cells keep connection under normal conditions, but if the cells are under pressure, such as damage or calcium horizontal peak, they can be quickly disconnected.
The study emphasizes the important role of calcium protein at the adjustment of the gap connection, and proposes that the role of calcium protein leaves is like a “cork plug”, which can insert the opening of the channel during the chemical door control process. As Professor Peracchia, this “cork” model shows that the interaction between calcium protein and channels is affected by calcium levels and voltage, providing dual control methods. He also pointed out: “The channel connecting the gap connection has two doors to respond to changes in the internal chemistry and electrical environment of cells.” This model helps clarify the new therapy of how to adapt to physical changes and develop diseases that destroy cell communication. Potential impact.
In addition, the study discussed how these discoveries affecting all parts of the human body, including the heart, the liver, and the brain, where different types of connecting proteins were found. The study emphasizes that the behavior of these channels may change according to the specific connectin involved, and these connectors are affected by its unique sensitivity to chemical and electrical signals.
Finally, Professor PERACCHIA’s research provides valuable insights, which can carefully adjust these dual door control mechanisms in the interval channel to maintain appropriate communication between cells. These discoveries opened the door for future research to explore the potential treatment methods that might adjust the gap connection under the condition of damage to cell communication.
Journal reference
PERACCHIA, C. “Gap connection channel adjustment: the story of the two gates-the chemical gate and chemical sensitivity voltage sensitivity of the fast voltage door.” International molecular science magazine, 2024. Doi: https: //doi.org/10.3390/ijms25020982
About the author
Camillo Pracchia It is the Honorary Professor of Pharmacology and Physiology at the University of Rochester. In 1962, he received a master’s degree in Milan University (Italy). His research focuses on adjusting cell battery communication through a gap connection channel. In 1967, he obtained a certificate of the Education Commission of Foreign Medicine. He has published more than 100 papers, edited three books, and wrote two books. He is an invitation spokesman for more than forty international conferences and seminars, and was once an deputy editor of “The Magazine of the Cyrology of God”. In 1994, he was elected as a honorary member of “Societádimedicina E Scienze Naturali” (University of Parma, Italy). He was a member of the study of cell biology and physiology (CBY-1, NIH, 1990-94). He is a member of the Marquis. He has had respiratory science to medical students and cell biology professors. He was the director of the course of “Physiology-500 Course” (1985-88 and 1998-99), the co-leaders and parts of respiratory physiology in respiratory physiology (1986-99) and “human structure” courses. (2000-04). Because of his teaching, he was awarded Manuel D. Goldman Award (1998), Edward F.
