In a discovery that can reshape our understanding of the decline in cognitive capabilities, researchers have discovered how physical exercise directly activates the insulin response system of the brain, which may open a new way for preventing dementia.
The team of New Baiyuk University at the University of Rogers discovered that the medium and high-intensity movement will trigger special brain cells to release protein that is crucial to the sensitivity of insulin-the ability of the human body to effectively use blood sugar. This mechanism can explain why regular physical exercise helps maintain cognitive functions with age.
“This work is important because it shows that exercise may improve cognition and memory by improving insulin’s ability to the brain,” said Steven Malin, associate professor of the Department of Sports and Health of Rogers. Item research can improve the effect of insulin on the brain. “” “.
The focus of the study is called the micro -cell structure of the neuronal cell vesicles, which are necessary to transport the essential protein between brain cells. In the past 15 years, these vesicles have been regarded as “cell dust” and have been recognized as an important participant in cell communication.
In the two -week trial, 21 participants with diabetes had an average of 60 years of age and completed the one -hour exercise with twelve supervisors. Researchers analyzed blood samples before and after the training plan, and found that the sac balp level carrying insulin sensitive protein increased, especially a protein called AKT.
Malin pointed out: “For the first time, we show that the exercise will affect the insulin signal conduction of neuronshow pipe is related to the clinical improvement of blood sugar.”
These meanings are beyond the prevention of diabetes. Insulin plays a key role in memory formation, cognitive treatment and communication between brain cells. When brain tissue is resistant to insulin, it may cause cognitive dysfunction similar to Alzheimer’s disease.
Malin explained this collapse in an analogy: “This is like playing games with friends. At some time, when the brain becomes insulin resistant, the information will be lost.”
Although previous studies have shown that rising blood glucose can damage learning and memory, the exact mechanism that associates exercise with the function of improving brain function is unclear. This study provides specific evidence to show how sports activities can help maintain cognitive health.
The research team includes scientists at the National Institute of Aging of the National Institute of Health, which is now investigating whether a sports conference can enhance the brain’s response to insulin. They are measurement of cerebral blood flow and track these cell messengers of obesity elderly people.
These discoveries are published in the magazine of aging cells, indicating that the insulin response system that targeting the brain may lead to a new treatment method that causes decline in cognitive ability. For the Americans who are facing dementia risk of millions of Americans, this study provides hope that regular exercise can help protect their brain health.
Other contributors to the study include Herbert and Jacqueline Kries Klein Alzheimer at Rutgers Robert Wood Johnson, Michal Beeri) and PhD candidate Daniel Battillo. The National Institute of the National Aging team includes Dimitrios Kapogiannis, Maja Mustapic and Francheska Delgado-Peraza.
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