Resocialization is key to anxiety and social memory disorders caused by long-term social isolation
It is worth mentioning that Professor Daniela S. Rivera, Professor Carolina B. Lindsay, from the Mayor of the University of Chile, and Dr. Carolina A. Olivia from Andres Bello University, worked with Professor Francisco Bozinovic and Professor Nibaldo Inestrosa C. De Chile investigates the long-term effects of chronic social isolation pressure on DEGUS behavior (Octodon degus) as a model, published in Neurobiology of stress Magazine.
Professor Rivera and colleagues use novel open-field and light dark box tests to evaluate the effects of chronic social isolation stress on anxiety in men and women degus, When they have similar genetic and physical characteristics to humans. Open testing is the primary screening of rodent anxiety as it measures new environmental exploration and general motor activity. Using the number of light/dark transitions performed by subjects, a light box test was used to measure the tendency to avoid stress conditions.
Their research shows that men degus Showing insecurity and women degus It shows hesitation to venture into the dark transition, thus confirming the physical nature of these communists.
Leadership author Professor Rivera said: “We evaluated for the first time behavioral responses to anxiety and socially related tests, as well as the characteristics of certain brain-related proteins in adults, women and men who have previously suffered from chronic social isolation stress from postpartum and after weaning to adulthood.”
Later, they observed that resocialization triggered obvious physiological, functional and molecular modifications after significant physiological, functional and molecular modifications were performed in memory-related tasks. In addition, the research team showed that social memory, such as social memory, will be affected by social isolation Octodon dEgus. They also evaluated the effects of chronic social isolation stress on oxytocin-level pathways in the hippocampus, prefrontal cortex, and hypothalamus, and its effects if resocialized. The participation of oxytocin level pathways in stress reactions in animals is controlled by a comprehensive network of different molecular phases. Long-term chronic social isolation stress disrupts the pathway to oxytocin levels. The researchers also observed impairment of negative feedback cycles in the HPA axis and cognitive deficits associated with chronic stress animals. male degus Quality synaptic transmission that shows superior to long-term stress women degus.
This extensive study confirms that prolonged chronic social isolation stress leads to impaired social memory and leads to social modifications – permanent molecular changes observed in the oxytocin level pathway caused by prolonged chronic social isolation stress. As a result, both men and women degus Show different homeostasis mechanisms to deal with chronic social solution stress. They concluded that resocialization can restore behavioral changes but cannot regulate oxytocin-level pathways in areas of the brain’s social domain.
“Our study provides a comprehensive view of the impact of stressful conditions and its effects on highly social animals. More importantly, we demonstrate that resocialization plays a significant role in stressful situations, normalizing behavior. ” Professor Rivera said.
In summary, Professor Rivera and colleagues provide an idea of how social animals deal with stressful conditions. This also shows that re-socialization is a buffer for stressful situations. The findings of this critical study will guide future research on the impact of resocialization on humanity.
Journal Reference and Major Image Credit: Rivera, Daniela S., Carolina B. Lindsay, Carolina A. Oliva, Francisco Bozinovic, and Nibaldo C. Inestrosa. ““Living Together, Living Alone”: The Effect of Resocialization on Behavior Performance and Social Impacts of Protein Related to Brain-Related Proteins After Long-term Chronic Social Separation Stress.” Neurobiology of Stress 14 (2021): 100289.
Dr. Daniela S. Rivera – Biologist, Ph.D.
Dr. Daniela S. Rivera – Biologist, PhD major in ecology, PhD, Assistant Professor of Genomics, Center for Ecology and Environment, Mayor. Her research adopts an interdisciplinary approach between behavioral ecology, ecological biology, neurobiology, and microbiology (particularly the gut microbiota). Her work focuses on assessing the effects of changes in environmental factors such as diet, thermal fluctuations in the environment, early life stress and social relationships or lack of social relationships, related to changes in gut microbial communities and ultimately affecting host behavior patterns (i.e., social and fuzzy) food behavior) and physiology. This multidisciplinary approach is essential for understanding the functions of nested ecosystems and further understanding how the microbiome regulates host-level behavior and population patterns, such as foraging behavior or the development of behavioral disorders. Her research combines a variety of techniques (field and laboratory studies of animal behavior) as well as molecular and cellular gut analysis, immunity, metagenomics, physiology, and evolution. She has several animal models such as insects, amphibians, lizards, snakes and small mammals.
DR (C) Carolina Lindsay Brain – PhD student
(C) Carolina Lindsay Brain – PhD student with a PhD in Biomedical Sciences from the University of Chile. She completed her undergraduate studies in 2017 and received her Master’s Degree in Biochemistry, where her research focuses on research on behavioral and neurobiology of age-related cognitive impairments Octodon degus. Her current research line is designed to elucidate the electrophysiological mechanism behind active visual perception, which is precise motion modulation during free movement tasks through the temporal precise motion modulation on the spikes and – on-site potential display of the main visual cortex. In addition to the research, Carolina has participated in appraisers and professors at the University of Chile’s School of Medicine, as well as several educational programs at the Center for Aging and Regeneration, with Children and Adolescents, the Institute of Biomedical Neuroscience and the Explora Program.
Dr. Carolina A. Oliva – PhD biologist in neuroscience
Dr. Carolina A. Oliva – PhD Biologist In neuroscience, research scientist, biophysicist with extensive experience in electrophysiology. Her work focuses on some of the most socially relevant diseases, such as neurodegenerative diseases, which are associated with the degeneration of specific circuits in the brain, causing emotional and cognitive impairments to gradually worsen until death. She uses In vitro model Different types of oscillating active circuit specificity can be generated to be studied at the level of cells, circuits and neuronal networks, the progression of major neurological diseases, and to predict whether certain brain circuits are more susceptible to neuronal function than others obstacle. To study synaptic transmission and integration, she combined electrophysiological recordings of multiactive activity, single recording of cortical neurons, and microscopic imaging of synaptic ends and dendritic spines to visualize the activity of cell binding along different post-age ages . Studies on protein expression patterns, such as proinflammatory molecules in specific regions, or metabolites released in activity-dependent forms, such as subtypes of amyloid beta peptides, are used to supplement the complex characteristics of these diseases. She has extensive experience in animal models, ranging from flies to rodents such as mice, mice and degus.
Dr. Francisco Bozinovic – Complete Professor
Dr. Francisco Bozinovic – Complete Professor at the University of Pontificia. Chief Researcher and Deputy Director of the Center for Applied Ecology and Sustainability. He is also the deputy director of the UC-Lower Syndrome Center. His research line focuses on the field of integrated biology, which brings together a wide variety of disciplines that complement each other to reveal the complexity and diversity of biological systems. He works with organism types and levels of biological fusion from molecules to biomes. His professional and children’s outreach books include over 300 mainstream scientific articles and authors of 5 books. He is a member of the Chilean Academy of Sciences and the Latin American Academy of Sciences and has received grants, awards and scholarships from the University of Chile, the Andes Foundation (Chile), the Carnegie Museum of Natural History (USA), and the JS Guggenheim Foundation (USA). In addition, he won the Scopus-Elsevier Award, the Medal of Science and Culture of the Croatian Community, the Excellence Award from the Chilean Ecological Society and the Atenea Award from the University of Concepsi. He was awarded a degree from Dr. Honoris Causa by the Australian University (Austral de Chile) and received the National Natural Science Award in 2020
Dr. Nibaldo C. inestrosa – Complete Professor
Dr. Nibaldo C. Inestrosa – Complete Professor at the Pope Catholic University of Chile and Director of the Center for Aging and Regeneration (CARE) in Santiago, Chile focuses on the study of innovative treatments to deal with Alzheimer’s disease and Alzheimer’s disease with Fighting with the ongoing disasters related to it. Dr. Inestrosa is an expert in neurobiology and is particularly interested in neurodegenerative diseases such as Alzheimer’s disease and their relationship to Wnt signaling pathways. He is also director of the Magallanes Centre of Excellence in Biomedical in Punta Arenas, Chile. He is the author of approximately 370 scientific publications in famous scientific journals and has directed 34 doctoral dissertations and 38 undergraduate dissertations. His work has cited close to 26,105, with an H index of 86 (Google Scholar), and in 2008 he was awarded the Chilean Natural Science Award.
