Grey hair is a common part of aging that many people want to delay or avoid. Although the beauty industry offers a variety of cosmetics to cover gray hair, there are still few options supported by science, which can actually slow down the process itself. A new study by Japanese researchers offers new hope that a natural plant compound called lutein protein may help prevent hair from turning gray.
A team led by Professor Masashi Kato of Nagoya University and Chubu University studied how lutein affects hair color in specially reproduced mice, tending to be gray faster than usual. These findings are published in the journal Antioxidants.
Professor Kato and colleagues gave mice Luteolin in two ways: by applying it directly to the skin and feeding them. They also tested two other natural compounds, thioprotein and diamine, but these levels did not show the same benefits. Mice treated with lutein had less gray hair, especially when applied to the skin. Oral treatment also helps, although the effects are not as strong.
The study shows that lutein works by protecting special types of cells responsible for maintaining color. Keratinocytes and melanocyte stem cells that these cells (which are involved in building the skin and producing pigments) often get damaged or stop working properly as they age. Lutein helps keep these cells healthy and functional. Professor Kato explained: “Lutensin inhibits the increase in raised p16INK4A-positive cells, which refers to aging keratinocyte stem cells that gather in the root areas of the hair follicles.” This means that lutein helps prevent these cells from getting older and worn.
The process appears to work by reducing stress in cells caused by harmful molecules called oxidative stress, a kind of damage that occurs over time. It can also be opened between different types of cells in the hair by keeping important communication lines. As we age, this communication (called signaling) often breaks down, resulting in loss of pigment. Professor Kato added: “Lutensin improves signaling dysfunction between endothelial proteins in KSCs and receptors in MSCs.
This study adds to our knowledge about how natural compounds can help keep senescent cells in better shape. Although the study focuses on hair, the results may also apply to other parts of the body where aging works. Interestingly, the researchers also showed that lutein may block light hair caused by chemicals that trigger cellular stress, further supporting the general signs that lutein may help prevent aging.
Although more research is needed to confirm these results, the findings are promising. Lutein has been found in certain supplements and skin care products, which may make it easier to develop new treatments in the future. Professor Gato concluded: “These results are encouraging, the practical application of lutein as a drug that has an anti-irritating effect on human hair.”
Journal Reference
Iida M., Kagawa T., Yajima I., Harusato A., Tazaki A., Nishadhi Dasm, Taguchi N., KatoM. Antioxidants, 2024; 13(12): 1549. doi:
About the Author
Professor Massasi Gato He is an outstanding scientist in the fields of environmental and occupational health, with strong concerns about skin biology, stem cell behavior, and molecular mechanisms of aging. Professor Kato has led many studies at Nagoya University, affiliated with Chubu University, and has explored the interaction between environmental factors and biological aging, especially in the context of hair pigmentation and stem cell maintenance. He is known for his pioneering research using genetically modified mouse models to understand how cellular stress and aging-related changes affect skin and hair. His work integrates molecular biology, toxicology and regenerative sciences to discover potential therapeutic applications for aging-related diseases. In addition to research, he is also actively involved in academic leadership and mentoring, contributing to international cooperation and innovation programs. Professor Kato’s research has a significant impact on medicine and cosmetic health, providing new ways to address age-related changes through natural compounds.
