Air pollution, whether it is from family sources such as cooking and heating, or outdoor sources from vehicle emissions and industrial processes, pose a major threat to health. Almost the entire global population is exposed to the level of air pollution that is exposed to danger, and breathing air over the safety restrictions of the world’s health organizations. This extensive contact leads to various diseases, including diseases that affect reproductive health.
In today’s industrialization world, air pollution has become a silent but powerful threat to public hygiene and has a profound impact. Among them, the impact on men’s reproductive health has attracted great attention. Researchers led by Professor Stefan Du Plessis at the University of Medicine and Health Sciences by Dr. Temidayo Omolaoye and Mohammed Bin Rashid Medical and Health Science University, Dr. Lisa Ferguson, Dr. Lisa Ferguson and Yashth I RamSunder, and Dr. Bashir Ayad at Misurata University. question. Their discovery was published in the journal of antioxidants for peer review, clarifying the mechanism of air pollution that affects men’s fertility, and emphasized the role of oxidation stress.
Dr. Omolaoye explained that air pollutants can increase the generation of active oxygen (ROS), leading to oxidation stress, lipid peroxidation and DNA damage. Dr. Omolaoye said: “Air pollution is one of the main causes of diseases and environmental reasons in the world. It leads to millions of people’s death each year and has caused a significant contribution to the burden on global diseases.” These pollutants, whether family activities or industrial emissions, are both It has a serious impact on human health, especially male reproductive health.
Researchers have comprehensively reviewed the literature of human and animal research to evaluate the impact of air pollution on the quality of semen and male sexual health. They found that exposed to air pollutants and sperm concentration, reduction of motion and form, and DNA crushing are related to other genetic abnormalities. These findings emphasize the harmful effects of air pollution on sperm quality, and emphasize the need for emergency intervention measures to reduce these risks.
Animal research has always showed that air pollutants such as particulate matter, air dynamic diameter ≤ 2.5µm (PM2.5) And sulfur dioxide (therefore2) It can significantly reduce sperm count and movement, and increase abnormal sperm form. In a study, Sprugue -Dawley rats are exposed to PM2.5 Show the decrease and abnormal form of sperm count. Similarly, exposure here2 It is found that sperm quality can be reduced and the testicular shape can be changed.
Human research confirmed these discoveries. For example, a large queue survey in China shows that exposed to PM2.5 Afternoon10 A significant reduction of sperm concentration and exercise. Another analysis of the United States found that there is negative correlation between PM2.5 After a few months of contact, exposure and sperm movement.
The study also studied advanced parameters of semen analysis, including DNA fragmentization and chromatin integrity. Exposure to air pollutants can cause DNA -protein cross -linking, resulting in obvious DNA damage. Dr. Omolaoye pointed out: “DNA fragmentation caused by pollution is a key biomarker for sperm quality, indicating that environmental pollutants have a serious impact on men’s reproductive health.”
In addition, air pollution is related to the changes in gene expression through epigenetic modification (such as DNA methylation and group protein modification). These changes will destroy the normal function of inflammation, oxidation stress and DNA repair genes, which further exacerbates the impact of air pollutants on men’s fertility.
The study emphasizes the clinical significance of these discoveries. Excessive ROS produced due to air pollutants will cause the human body’s antioxidant defensive agent, which will cause oxidation stress and subsequent damage to sperm cells. The team calls for improving consciousness and measures to reduce contact with air pollutants, especially among fragile people. They suggested that public health policies should give priority to reduce air pollution to reduce their impact on men’s reproductive health.
In short, the study of Dr. Omolaoye and his colleagues provided convincing evidence to prove the adverse effects of air pollution on male reproductive health. By clarifying the mechanism involved, especially the role of oxidation stress, this study emphasizes that facing the rise in air pollution levels, and urgently need intervention measures to protect and improve reproductive health.
Journal reference
Omolaoye of TS; Skosana, BT; Ferguson, LM; Ramsunder, Y. ; Ayad, BM; Du Plessis, SS (2024). “The effect of exposed to air pollution on male reproduction: the effect of oxidation stress.” Antioxidants. Doi: https: //doi.org/10.3390/antiox13010064
About the author
Temidayo Omolaoye It is a professor of physiology at the UAE Dubai Mohommed Bin Rashid Medical and Health Sciences University. She is full of enthusiasm for research and believes that the continuous spread of knowledge obtained through this means is crucial. She is the winners of various awards, scholarships and research subsidies. Her core research interests include reproductive medicine/physiology, endocrinology, diabetes and reproductive poison science. At present, she focuses on the molecular mechanism of male infertility caused by diabetes caused by OMICS technology. She also served as a temporary reviewer of many well -known recognition journals.
Professor Stefan Du Plessis It is the dean of the study and graduate study of the University of Muhammad Ben Rashid Medical and Health Sciences in Dubai, UAE. His research interest is the field of men’s reproductive physiology, and it has produced 133 articles and nearly 5,500 citations by peer review. He must also get credit of 30 and 4 books, and supervise many doctoral and master students. He serves as the editorial committee of two international journals and temporary reviewers of various funding agencies and scientific journals. Professor Du Plessis was recently elected as a member of the Mohammed Bin Rashed Scientist College (MBRAS). He is a Class B -level researcher at the National Research Foundation, and the winner of the Fub Wedd Scholarship and other research and teaching awards.
Lisa Marie Ferguson In 2021, he obtained a master’s degree from the University of Stellenbosch (SU). The last year of the Reproductive Research Team (SURSG) of the University of Stellenbosch, the research team (SURSG) is located in the SU of SU and is located in the SU. Essence Her research interest focuses on exploring various elements that affect sperm function, and especially focus on the molecular basis that leads to sperm dysfunction. Her work helps a wider understanding of male fertility.
Yashthi Ramsunder It is a doctoral candidate in the field of male research in the University of Statunbos Research (Surrg). This is a laboratory in the Institute of Biomedicine of the University of Biomedicine at the University of Stelenbosch, Cape Town, South Africa. After completing a master’s degree in 2023, her research focuses on the impact of drug -based therapy and lifestyle factors on male fertility parameters. In addition, she also conducted a widespread research on the molecular framework of sperm function. In addition to work, Yashthi is an enthusiastic bakery and an active member of the physiological research community. He often speaks and guides ambitious physiological researchers at the meeting.
Bashir Mohammed Ayad He is currently the director of the Department of Physiology of the University of Misurata and a assistant professor at the Department of Physiology of the University of Misurata. He graduated from BSC (1998), MSC (2009) and PHD (2018) degrees. He supervised and inspected many graduate students and doctoral students. His research interest lies in the field of cell physiology ,rogen, endocrinology, respiratory science, DNA crushing and oxidation stress. He has actively cooperated with other well -known scientists from all over the world, especially Professor Stefan Du Plessis (Research and Graduate Research Dean, Professor of Physiology of Dubai Medical College, UAE), UAE) and other internationally renowned scientists. He has published many scientific articles and book chapters that have been reviewed by colleagues. He is a regular temporary temporary manuscript for many countries and international science journals. [email protected]
