It has been shown that a drug developed at the University of Texas at San Antonio has been shown to expand survival in patients with glioblastoma, the most common primary brain tumor in adults.
The results of the university-led trial showed that the median survival and progression-free time of a unique study drug called Rhenium Obisbemeda (186RNL) had more than twice the median survival and progression-free time, and had no dose-limiting toxicity effects compared to the standard median survival and progression rate.
“As a recurrence model, resistance to chemotherapy and difficult to treat diseases, glioblastoma requires durable treatments that can target tumors directly while retaining healthy tissue.” “This trial offers hope and is scheduled to be completed by the end of this year.”
Brenner, also a clinical investigator at the UT Health San Antonio Institute for Drug Development and co-leader of its experimental and development treatment programs, is the lead author of the trial study titled “Convection enhances Rhenium’s delivery (Convection) (186re)obisbemeda(186RNL) in recurrent gliomas: multicenter, single-arm, phase 1 clinical trial. “It was published in the magazine on March 7 Natural Communications.
Other authors also work with the MAYS Cancer Center and the UT Southwestern Medical Center in Dallas, Case Western Reserve University, Anderson Cancer Center, and trial sponsor Plus Therapeutics Inc. (NASDAQ:PSTV), a clinical-stage pharmaceutical company that has obtained the CNS Cancers Cancers Cancers Cancers Cancers the Firake Technology of Beartialical Pharmaceical Companical of Fight.
Brenner said the median overall survival time for surgical, radiation and chemotherapy failure in patients with glioblastoma after standard treatment was only about eight months. More than 90% of patients relapsed the disease in their original location.
rhenium obisbemeda can deliver specific activity (186RE) (186RE) through tiny liposomes (186RE), which refers to artificial vesicles or vesicles of at least one lipid bilayer. The researchers used a custom molecule called BMeda to chelate or ligate 186RE and transport it to the interior of the liposome and capture it irreversibly.
In this trial, known as the Phase 1 Respect GBM test, scientists set out to determine the maximum tolerated dose and safety of the drug, overall response rate, disease-free survival without disease progression and overall survival.
After failing one to three therapies, 21 patients who were studied from March 5, 2015 to April 22, 2021 received medications that were treated directly with neurological drive and convection catheters.
The researchers observed a significant improvement in survival compared to historical controls, especially in patients with the highest absorption doses, with median survival and progression-free time of 17 months and 6 months at doses greater than 100 gray (GY), referring to the radiation unit.
Importantly, they did not observe any toxic effects of the restricted dose, and most adverse effects were not associated with the study treatment.
“The novel nano-type radiation therapy provided by convection-enhanced delivery, facilitated by neural-driven tools, catheter design and imaging solutions, can successfully and safely provide highly absorbed radiation doses to tumors with minimal toxicity and potential survival benefits,” concluded Brenner.
Information on the Respectful GBM Trial Phase 2 of the Active Recruitment of Patients can be found here.
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