Anemia is a extensive health problem, especially in children and women of reproductive age. Although there are medical progress, many anemia treatments have not declined due to the poor absorption of iron supplements, unpleasant side effects, and daily doses that may be difficult to persist. Imagine that you can wear a simple patch, you can have no pain within a few days, and effectively transport the necessary iron directly to your body, so that millions of people are easier and reliable.
Researchers at the Institute of Life Sciences, Dr. Reddy, led by Dr. Marina Rajadurai, developed a novel transparent film with Parimal Misra, Bhavya Surekha and Aiswaya Madathil, and provided a new type of new type of nanometer with iron (II). Through the scripture is used to combat iron lack of anemia. This innovative patch is published in the “Material Progress” magazine. It uses microneedles to transfer iron directly through the skin to bypass the gastrointestinal system, which will usually lead to poor absorption and significant side effects in conventional oral iron supplements.
Iron deficiency anemia is still a key global health problem, especially children and women who affect reproductive age. The current treatment is facing major challenges, including low biological utilization of oral iron supplements, low side effects of unpleasant side effects, and patient compliance issues. The research team tries to solve these problems by designing a biodegradable patch. This patch can not only provide continuous iron release for a long time, but also minimize the initial iron explosion that may cause adverse reactions.
The micropores made of biodegradable polymers are embedded in iron sulfate nano particles (IS NPS), which aims to release iron for nearly two weeks in control. The micro -needle is small, but it is valid for painless transparent skin delivery without bringing obvious discomfort to users.
in vitro The test of the plaque shows that it has achieved most of its drug release throughout the duration and released within a few hours after the approaching linear mode. It is worth noting that when testing on pig skin models, the initial outbreak of iron is usually challenges in similar transmission systems. This controlling release is essential to ensure that patients receive stable iron doses without experiencing gastrointestinal problems.
Dr. M. Rajadurai emphasized the importance of this innovation. He pointed out: “Our micro -needle plaques represent major progress in the treatment of iron deficiency anemia. By providing the release of continuous and controllable iron, we aims to improve Patient’s results and reduce the burden on global diseases. “
The study also included investigations conducted by Dr. Anitha C. Thippaiah, as well as Professor Bindiganavale R. Shamanna in medical care professionals and potential beneficiaries. The survey shows that the patch is popular, especially among urban residents and healthcare providers, they recognize their potential for improving the compliance and effectiveness of anemia treatment. However, the survey also emphasized the need for additional education and exterior in rural areas. In rural areas, traditional replenishment methods are more common.
Looking forward to the future, the research team plans in vivo Study the efficacy and safety of plaques. These studies are essential for determining the potential of the extensive clinical use of plaques, and it may be paved with the new standards for anemia. Especially in areas that comply with oral supplements are a major challenge.
In short, Dr. Rajadurai and her colleague’s innovative micro -needles are affixed with iron (II) nanometer particles, which provides new ways to manage new methods of lack of anemia. By solving the shortcomings of the current treatment, their work may improve the quality of life of millions of people suffering from this situation worldwide.
Journal reference
Bhavya Surekha, Parimal Misra, Anitha C. Thippaiah, Bindiganavale R. Shamanna, Aiswaya Madathil, Marina Rajadurai. “A micro -needle transparent patch with iron (II) nanoparticles is used for non -invasive continuous delivery to fight anemia.” Materials advance (2024). Doi: https: //doi.org/10.1039/d3MA01166F
About the author
Dr. Marina Rajadurai He obtained a master’s degree in chemistry from the Russian University of Chemistry in 1998, Russia. Then, she served as an engineer for four years at the Nesmeyanov Research Institute of Nesmeyanov at the School of Sciences, Russia and Russia, and then joined the doctoral degree in the same research. In 2006, she completed her doctorate degree. During this period, she also served as a visiting graduate student at Max Planck Polymer Research Institute in Mainz, Germany.
In 2008, Dr. Rajadurai became a postdoctoral researcher at the Institute of Life Sciences of Hendraba. Her research focused on the design biological imaging of pharmaceutical chemistry and new fluorescent nanomaterials. In 2010, she was appointed scientists at the Reddy’s Life Sciences of the Reddy’s Life Sciences of Hyderabad, and she continued to be the association today. Chief Research Scientist.
Dr. Rajadurai’s current research is concentrated in the development of nano -particle -based drug transportation systems. She uses an innovative method to create an efficient and effective drug conversion mechanism, including microneedle technology, lipid nanoparticles, and hydrogel nano and particles. One of the focus of her work is to control the shape and size of the high -level biological activity compounds of nano and sub -micron to enhance her biological activity. Her group is committed to finding an innovative solution to deal with existing challenges in resistance and nutritional deficiency.
