Fixing bone injury may soon be as simple as combining natural stem cells with enhanced materials. Due to the innovative research on bone regeneration, this exciting possibility is becoming reality. By using advanced technology to treat materials and use the power of stem cells, scientists are developing new methods to promote faster and more effective healing of bone defects. This pioneering method can completely change the treatment of patients with bone injury, thereby providing new hope for improving rehabilitation and better results.
Dr. Majamiletić, Dr. Slavkomojsilović, and colleagues from the University of Belgras have recently proven to have made major progress (β-TCP) in bone regeneration with PDLSCS. Their research published in the magazine of Applied Science, emphasizing the enhanced potential and reduced inflammation of inflammation related to this innovative treatment method.
Researchers explored the recycling capabilities of β-TCP used by CAP and sowing PDLSC. The research in the body uses the critical size defect model of the alumni alumni to evaluate the bone healing of two weeks and four weeks. Histores and organizational analysis show that compared with the use of β-TCP alone, the bone regeneration and inflammatory reactions combined with the combination of β-TCP and PDLSC with CAP pre-processing significantly improved significantly.
Dr. Miletic explained: “Our results show that the combination of β-TCP and PDLSC treated by the cover has significantly enhanced bone regeneration and reduced inflammation, indicating that there is a future for the treatment of bones.”
The study determines the protein (BMP-2 and BMP-4), the transcription factor 2 (Runx-2) related to RUNT, the significant increase of collagen-1 and osteopl edge, which is a key sign of bone healing. The expression of these tags is significantly higher in the group of β-TCP and PDLSC processing pre-processing of caps, indicating that the initial phase of bone formation accelerates.
Dr. Mojsilovii emphasizes the importance of surface modification in enhancing the regeneration potential of biomass materials. He pointed out: “CAP processing has changed the surface chemistry of β-TCP and improves its interaction with stem cells and host tissues, which is essential for successful bone regeneration.”
This study has opened up a new way to formulate a advanced bone tissue engineering strategy combining stem cell therapy with CAP technology. Hopeful results show that this merger method may be effective and relatively simple methods for treating bone defects, and may improve the prognosis of patients with bone disease.
In short, Dr. Mileti ，, Dr. Mojsilović, and his team have taken an important step in bone regeneration research, innovatively used the β-TCP and PDLSC of CAP pre-processing. These discoveries have laid the foundation for future research to explore the widespread application of this combination method in regeneration medicine. This breakthrough not only provides a promising treatment strategy for patients with complex bone injuries, but also opens up new ways for the effectiveness of the existing treatment. With the development of research, this combination technology may lead to more easily and effective bone repair solutions, and ultimately improve the results of patients and quality of life. This work emphasizes the importance of cross -disciplinary cooperation in promoting medicine and development and innovation solutions for long -term health challenges.
Journal reference
Maja Miletic, NEVA PUAC, Nikolaškoro, BožidarBrković, Miroslavandrić, Bogomirbolkaprokić, VesnaDanilović, Sanjamilutinović-Smiljanić, Oliveraa Mitrovij-Ajti-Oliveramitrović-Ajtić and Slavkoć “The bone regeneration potential of peripheral ligament stem cells and cold atmospheric plasma pre-treatment Diaphotate: Evaluation in the Body. “Application Science (2024). Doi: https: //doi.org/10.3390/app14010016
About the author
MajamiletiaAssociate Professor of the School of Dental Medicine at the University of Belgrade, a doctorate degree in dentistry, has a master’s degree in dental degree and a doctorate in medical science. She is currently the head of the Department of Path physiology and actively participated in a doctorate research, that is, the basis and clinical study of dental research plan, where she supervised three courses there. So far, she has always been a mentor at several doctoral dissertations at the School of Dental Medicine at the University of Belgrade. Her current research focuses on the impact of inflammatory micro -environment on the recycling characteristics of inter -medal cell cells. The pathogenesis of the fundamental process and the application of non -thermal atmospheric plasma in biomedical in biomedicine. She participated in three countries and two international research projects: “Control control: choose and analyze different oral tissue as the appropriate correspondence of the top tooth periodic lesions” (2019–) and “in the development Evaluation and evaluation of genetic factors-a multi-center research funded by the European Internal Condition Society (2023-). She has published 22 papers in the Journal of SCI-IDEX.
Slavkomojsilovi sSenior research assistant is a doctorate in medical and immunology experts with doctoral degrees. He is currently working at the University of Hematology and stem cell group. His research focuses on the effects of studying inflammation and tumor microenvironment on the impact of interstitial cells and hematopoietic cells immune regulation and regeneration characteristics. The fields he are interested in studying stem cells in the context of inflammation, hematopoietic, recycled medicine and oncology. So far, he has participated in many research and technical development projects funded by the Department of Science and Technology Development of the Republic of Serbia, as well as several international research projects and cooperation, including cost measures, bilateral projects and sixth frameworks. ) Project research and technological development. He wrote 81 publications, referenced 1158 times, and H-index was 18. In the past six years, he has been the secretary of the Scientific Committee of the Institute of Medicine and is currently a member of the board of directors of the Serbian Institute of Immunoh.
Dr. Nevenapua n It is the main researcher of the Belgrade Institute of Physics, the main researcher of the Institute of Physics in low-temperature plasma-low and atmospheric pressure plasma, and many diagnostic methods and application experts of plasma in biology, medicine and agriculture. She received a doctorate at the University of Belgrade, and part of the paper was completed at the TECNICO Institute in Lisbon, Portugal. She was a PI (TD 23016, Education, Science and Technology Development Department, 2008-2010), multi -disciplinary projects (III41011, Ministry of Education, Science and Technology Development, 2011-2019) and PI. In bilateral projects. At present, she is Plagri-CA19110, chairman and coordinator of the cost of cross-disciplinary costs, “plasma agriculture of intelligence and sustainable agriculture”, and is the leader of the Marie Sklodowska Purie ITN project of the Institute of Physics. She published more than 70 articles in international journals and publications. Her H index is 29, with more than 2,400 references. Most of the papers she published in her published in biology and medicine in plasma. So far, she has supervised several doctoral degrees and masters and diplomas. She is the co -chair and organizer of several conferences and seminars.
Dr. Nikola SkoroThe chief researcher worked at the non -balance process center of the Institute of Physics at the University of Belgrade. The theme of scientific research belongs to the field of cold and other ionic diagnosis (the plasma optical transmission spectrum and ICCD imaging distinguished by space and time; the power measurement value) and the application of plasma on the sensitive surface, polymer and textiles, and biological biological biology in ions and other ionic. Medical plasma treatment liquid samples use atmospheric pressure plasma (pollution, plasma activation water and medium, cell treatment). He is currently the chief researcher of the conceptual verification project and several bilateral cooperation projects, and is the head of the work plan of Appleenter-Biom (No. 7739780), funded by the Science Foundation of Serbia. He is a researcher at Marie Curie, and has participated in several international and national projects as the person in charge of the task. He has published 27 articles in international journals. His H index is 14 articles, with more than 350 citations. Most of the papers he published in his publishing belong to the field of plasma applications for the treatment of biology, medicine and liquid targets. He gave a speech more than 15 invitation at the famous international conference.
