The earliest stage of life depends on a series of subtle processes, and even small damage can prevent embryos from being successfully planted into the uterus. One of the key factors in this process is an enzyme called hemotin oxyrase-1 (HO-1). This enzymes play an oxidation and support the formation of blood vessels in the uterus. Relaxing an important role. When lack of HO-1, this careful balance will be abandoned and facing major challenges in the early stages of pregnancy.
A pioneering research shows that the lack of HO-1 has severely damaged the implantation process, which is a key event in the early stages of pregnancy. This enzyme is encoded by HMOX1 genes and participates in various physiological processes, especially in the reproductive system. This study was Dr. Maria Laura ZenClussen from the University of Leipzig University, Dr. Schumacher, Dr. Schumacher, and Dr. Sina Ulrich, Dr. BEATE FINK, Dr. Sina Ulrich. Eate Fink cooperates with ANA Claudia ZenClussen. The molecular mechanism that connects the HO -1 deficiency with the implantation failure and the uterine coercion. Their work has been published in the “cell” magazine.
Hemorrin oxyrase-1 is critical in the degradation of free hemoglobin to carbon monoxide (CO), free iron and bisoprotein degradation. These by -products are essential for alleviating oxidation stress and promoting vascular development, especially in the uterus during pregnancy. The study emphasizes the serious consequences of HO-1 deficiency, including damaged implantation and genetic disorders related to uterine stress and vascular generation.
Dr. ZenClussen, Dr. Schumacher, Dr. Meyer and his team used the human nourishing cell line to use innovative in vitro models to simulate the implantation process. They observed that HO-1 in these cells caused them to be significantly reduced to adhere to the endometrium epithelial cells, which is a key step for successful implantation. Specifically, when HO-1 silent, the attachment rate decreases significantly. This discovery strongly supports HO-1 is vital to implantation.
Interestingly, researchers have also discussed whether the negative effects of HO-1 knocking down can be reversed by one of the by-products reacting by HO-1. They found that the sphere can be treated with CO to restore its ability to attachment equivalent to unprocessed control. This shows that CO may make up for the lack of HO-1 by imitating its protection effect during implantation.
Further analysis expands to mice’s body experiments, which shows that HO-1 lack of uterus (HMOX1– / –) Women show the obvious disorders of participating in stress reactions and vascular generation of key genes. It is worth noting that in the uterus with insufficient HO-1, it has clearly lowered the DNA repair that protects cells from oxidative damage and genes involved in GSTM3. The lowering indicates that there may be oxidative stress in the uterine environment without HO-1.
In addition, the study determines the significant changes in the expression related gene expression in HMOX1– / – Uterus. For example, gene EPAS1 related to hypoxia reactions is basically raised, and for vascular development (such as VEGFC and leptin), several essential genes are essential. This imbalance of gene expression may cause implantation damage observed in the HO-1 defective environment.
The group also checked the gene expression of the 14th day of pregnancy in HMOX1– / – Rats have found that the level of inflammatory cytokines and tendred factors is elevated, which is essential for medium immune response during pregnancy. The excessive expression of these molecules may create an inevitable environment for the developmental embryo, which further exacerbates the implantation difficulties caused by the lack of HO-1.
Dr. ZenClussen, Dr. Schumacher and Dr. Meyer said: “Our results strongly indicate that HO-1 is essential for successful implantation, and its absence of environment that causes lack of uterus may hinder the early stages of pregnancy.” These are these. “These are these stages.” These are these stages. ” It is found that the importance of HO-1 in the uterine environment that is conducive to implantation and early pregnancy development.
Dr. ZenClussen, Dr. Schumacher, Dr. Meyer and his colleagues believe that this research not only improves our understanding of potential molecular mechanisms, but also opens up new ways to explore the treatment strategy. By affecting HO-1 and its by-products (such as CO), they suggest that intervention measures can be formulated in the absence of HO-1 deficiency or dysfunction.
Journal reference
ZenClussen, ML, ML, Ulrich, S., BAUER, M., FINK, B., ZenClussen, AC, Schumacher, A. , & Meyer, n. (2024). “The lack of hemoglobin oxyrase-1 will affect the implantation of the sphere of nourishing cells and cause disorders in the uterine pressure and genetic expression of blood vessels.” Cells, 13,376. Doi: https: //doi.org/10.3390/cells13050376
About the author
Maria Laura ZenClussen He is a scientist at the Argentine National Science and Technology Research Commission (Conicet) and works at the University of NaCional Del Litral, St. Dafei, Argentina. Her current research focuses on the impact of environmental estrogen and hemoglobin-1 on pregnancy.
Before joining Conicet, Dr. ZenClussen was a postdoctoral researcher in Germany, located in Charité-UNIVERSITSMEDIDIZINBELIN, and OTTO-Von-Guericke University (OVGU) Magdeburg.
Dr. ZenClussen received a doctorate degree. From the University of Berlin, Germany, it focuses on the role of hemoglobin oxyrase-1 in the tolerance of FETO mothers. She studied biotechnology diploma at NaCional Del Litral University in Argentina.
Dr. Annie Schumacher He is a senior researcher at the HELMHOLTZ-CENTRE Department of Environmental Immunology. It is used for environmental research and leaders of the “perinatal immunology” of the working group on the Saxon clinical translation medium. In her scientific career, she has gained important experience in immune -driven reproductive complications and other immune -related diseases. At present, her research is the interface between environmental chemicals, immunology and reproduction, aiming to reveal the impact of immunotoxicity and anti -toxicity of environmental chemicals, and support regulatory authorities in the decision -making of chemical regulations.
Dr. Nicole Mel It is the scientist and group leader of the Helmholtz Environmental Research Center (UFZ) LEIPZIG, specializing in environmental and reproductive immunology. Her research focuses on the impact of environmental chemicals on the congenital immune system and her impact on vascular disease and allergies. She also led the “in vivo and in vitro imaging” platform and manages projects such as “EMPRECHEM”, which aims to give pregnant women’s power through the understanding of environmental chemical risks based on application.
Before joining UFZ, Dr. Meyer was a postdoctoral researcher at OTTO-Von-Guericke University (OVGU) Magdeburg. There, she is engaged in the effect of research on environmental estrogen and hemoglobinylase-1 on pregnancy.
Dr. Meyer obtained a doctorate degree from Ovgu Magdeburg, focusing on the participation of large uterine hypertrophic cells and natural killing cells. She is studying biological diplomas at Dresden University
