When our skin is injured, the complicated process begins to cure wounds. Claiming cells (cells that constitute the outer layer of the skin) are collectively moved to narrow the gap. However, researchers have found that protein piezoelectric 1 can interfere with this process and slow down wound healing. Understanding the role of voltage 1 in cell movements may lead to new methods to enhance wound healing, which benefit many injuries and chronic wounds.
Researchers at the University of California Owen, California, found the key role in cell migration during regulating wound healing. The study led by Professor John Lowngrub and Professor Medha Pathak and Dr. Jinghao Chen, Dr. Jesse Holt and Dr. Elizabeth Evans were published in the magazine of “Plos Computational Biology”. The study reveals how to suppress the formation of leading cells, which is essential for coordinated cell migration to affect the wound healing process.
Leading cell transmission machinery and biochemical signals formed on the edge of the wound, which coordinate the movement of automatic cells to close the wound. Researchers combine the combination of experimental methods and mathematical modeling to study the role of voltage 1 in the process. Their discovery shows that the voltage 1 activity inhibits the formation of these leading cells, leading to a well -organized and slow wound closed.
Dr. Chen explained the motivation of this study: “Understanding how Piezo1 regulates the formation and coordination of the cells during the formation of the cell migration, providing valuable insights for the mechanism of wound healing. Improve wound healing efficiency. “
Through delayed microscope and scraping wound measurement, the team observed that the volume of the piezoelectric 1 increased the cells that follow the cells along the edge of the wound, which inhibited the advancement of the cells required to close the wound. Experiments show that compared with normal or increased voltage 1 active cells, cells lacking voltage have more leadership cells, therefore more effective wounds are closed.
The research team also developed a new type of wound closed two-dimensional continuous model, which contains key factors, such as cell movement, retraction, cell-cell adhesion and coordination. This model enables them to simulate the impact of 1 on the migration of collective cells and verify their experiments. Their simulation confirms that the increase in voltage 1 activity will lead to a decline in coordination, thereby suppressing effective wound closures.
Dr. Chen emphasized the importance they discovered: “Our research provides a comprehensive framework to understand the biological physical mechanism of Piezo1 regulating collective cell migration. These knowledge can provide information for the development of new therapeutic strategies to improve wound healing.”
All in all, the study emphasizes the importance of mechanical clues in wound healing and provides potential goals for treatment intervention. Professor Lowengrub, Dr. Pathak and his team’s insights on the role of Piezo1’s role in the formation and coordination of Piezo1 during the formation and coordination of leaders during the formation of cell migration is the way to enhance the research of wound healing in the future.
Journal reference
Chen, J., Holt, JR, Evans, EL, Lowngrub, JS and Pathak, MM (2024). Cangers regulate the formation of leaders’ cell formation and cell settlement during the formation of collective keratin. PLOS calculate biology. Doi: https: //doi.org/10.1371/journal.pcbi.1011855
About the author
Jinghao Chen Recently, under the supervision of Professor John Lowngrub (John Lowngrub), he recently obtained a PhD in mathematics at the University of California. His main research interest lies in the field of computing and applied mathematics, focusing on mathematics biology. In this field, he has developed a mathematical model, which combines appropriate partial differential equations to effectively capture and study extensive biological models and phenomena. Jinghao’s work was funded by multiple gifts and awards, and he proposed his discovery at several international conferences.
