HAIS (HAIS) constitutes a major threat in the medical environment, which is usually caused by polluting surfaces and equipment. Although the sterilization scheme is strict, these infections will still occur, resulting in serious complications of patients. Researchers are constantly seeking innovative solutions to enhance the control of infection and protect the health of patients. A promising method is to use special antibacterial coatings that can be used in medical equipment and blood products storage bags, thereby reducing the risk of infection. The latest progress in this field shows that a biological polymer polymer to prevent huge potential to prevent HAI through its antibacterial characteristics.
Researchers from the University of Héma-Québec and Universitélaval have developed an innovative solution that can use unconnected polyamide (PDA) coating to fight these infections. This is Dr. Danny Brouard and Sahra Fonseca, Nicolas Fontaine, and Marie-Pierre Cayer This pioneering research led by Professor Jonathan Robidoux and Professor Denis Boudreau has published in the next material under the diary of peer review.
The main motivation of this study is to optimize the antibacterial effect of PDA coating to reduce the risk of transmitting bacterial infection. The team explores various conditions for synthetic PDA, including dopamine monomer concentration, sample positioning, stirring speed and reaction time. These parameters significantly affect the morphology and wetness of PDA coating, which affects its antibacterial characteristics.
One of the most noteworthy discoveries in this study is that PDA coating shows a reduction in bacterial load, especially for Staphylococcus aureusEssence However, the effectiveness of coatings is less effective in targeting E. coliAccording to the requirements of bacterial strains and application, further optimization is emphasized.
Researchers use advanced characterization techniques, including ultraviolet visible spectrophotic meters, contact angle measurement, and atomic microscope to characterize coatings. However, excessive roughness is not always related to better antibacterial properties, indicating that other factors (such as surface charge and hydrophobicity) also play a role.
It is important that the study also confirmed that PDA coating has nothing to do with human cells and may make it safe to apply medical application. Dr. Brouard added: “The minimum cytotoxicity of polydamine is a vital discovery because it can ensure the safety of these coatings in medical equipment.”
The potential application of this study is widely. By preventing bacterial adhesion and proliferation, the PDA coating can significantly reduce the incidence of HAI, leading to a safer medical program and improving the ending of patients. Researchers believe that future work should focus on enhancing the antibacterial characteristics of PDA through chemical modification and functionalization.
This research represents an important step for developing antibacterial materials for medical applications. By optimizing the comprehensiveness and application of PDA coatings, Dr. Brouard and his colleagues paved the way for new strategies to combat and improve medical care and safety.
Journal reference
Fonseca, S., FONTAINE, N., Cayer, M.-P., Robidoux, J., BOUDREAU, D. & Brouard, D. D. (2024). The synthesis and antibacterial properties of unresolved polytine coatings to prevent infection. The next material, 3,00161. Doi: https: //doi.org/10.1016/j.nxmate.2024.100161
About the author
Sahra FonsecaMSC is a researcher at the research department of the Héma-Québec research department. After completing a bachelor’s degree in microbiology in 2019, she obtained a master’s degree in biochemistry from Laval University in 2021 to evaluate the antibacterial and anti -adhesion performance of nano -particle coatings in biomedical applications. Her research focuses on the theme of nanomaterials, polymers, and blood products quality and safety.
Nicolas FontaineThe doctoral degree is a postdoctoral researcher at the Philippe Dauphin Duchaarme research team, who has been in the chemistry department of the University of Sherbrook. In 2017, he completed his post -chemistry science scholars with honor, and he received a doctorate degree in Laval University in 2022. His papers are about developing high -light nano sensors to detect metabolites of the intestinal microbes. He then moved to Sherbroke for electrochemical training. His research focuses on the theme of nanomaterials, optics and electrochemical sensors. Nicolas’s research is currently supported by FRQNT, which aims to enhance the analysis performance of bio -sensitive based on electrochemical -based bio -sensors to promote its deployment in real life.
As a part of their study at the University of Lawars, Nicolas and Sahra were required to work together to promote their respective professional knowledge. This cooperation further highlights the important synergy of Héma-Québec in microbiology and blood products, as well as the experience of Professor Boudreau’s laboratory in nanomaterials and representation. They jointly proved the importance of this cooperation in the continuous development of active materials and analysis methods in the field of microbiology.
