Evaluating kidney health often involves looking at a measure called glomerular filtration rate (GFR), which basically tells us how the kidneys work. However, it is not easy to achieve accurate measurement of GFR. Almost all the creatinine of the key substance used to estimate GFR is derived from our muscles. The effect of muscle mass on serum creatinine complicates the assessment of kidney health. As you age, muscle strength and volume decrease, this disease is called sarcopenia. Starting around 30, this loss has a significant speed in the 60s, which may cut muscle mass in half and cut it into 80s.
A recent study was led by Professor Jeong-ho Kim from Yonsei University School of Medicine and was conducted with Professor Jisook Yim from the Korean University School of Medicine, Professor Nak-Hoon from Keimyung University and Professor Taeyoung Kyong and Professor Yongjung Park, Professor Yongjung Park Also from Yonsei University School of Medicine, this complex relationship is explored with a focus on the elderly. Their study, published in the journal Heliyon, examines the role of age and gender in the link between muscle mass and serum creatinine levels in healthy older adults. population.
The study examined data from a large number of participants from the Korean National Health and Nutrition Examination Survey (KNHANES) and Health Examination (HC) groups. The team used bioelectric impedance analysis techniques to measure serum creatinine levels and skeletal muscle mass index (SMI), which are muscle-rich. They found that in older men, muscle volume is more obvious with age than in women. This decrease in the bulk of male muscles also corresponds to a decrease in serum creatinine levels in the knhanes and HC groups. In contrast, the relationship between creatinine level and age was less obvious in women in both groups.
Professor Zhong Gao pointed out that there is an important discovery in their work, pointing out: “Because men have more obvious muscle mass, the creatinine level in elderly men is higher than that in elderly women.” This discovery highlights the The importance of gender differences in evaluating kidney health in older people is advocated for the adoption of gender-specific approaches in these assessments.
The team also created a model to predict creatinine levels, taking into account factors such as muscle bulk, age, and gender. This model shows that these factors can be used to explain a large portion of the variability of creatinine levels in knhanes and HC groups. The formula developed in the study helps to understand the interactions of muscle mass, age and gender that affect creatinine levels.
In his closing speech, Professor Jin emphasized the broader meaning of their study: “The difference in muscle mass reduction between older men and women is crucial for accurate GFR calculations. Muscle bulk declines significantly in older men, which is more important than in older women’s muscle mass. Stability and even increase compared to call for a re-examination of age-related factors in GFR calculations for different genders, especially for those over 65 years of age. “He stressed the need to conduct ongoing research to ensure the number of older people More and more patients are in a healthcare setting.
In summary, this study elucidates the important role of muscle mass in serum creatinine levels, especially in older adults, and highlights important differences between genders in this regard. It advocates a gender-specific approach in estimating kidney health in older people. This study not only deepens our understanding of kidney health assessments, but also provides a path to more personalized and precise health care for older people.
Journal Reference
Jiok Yim, son of Nak-hoon, Taeyoung Kyong, Jeong-ho Kim, “The effect of muscle mass on serum creatinine levels in older men is greater than that in women”, Heliyon, 9 (11) (2023) (2023). doi:.
About the Author
Dr. Jisook Yima clinical assistant professor at the Korean Arnum Hospital, South Korea’s School of Medicine, specializes in clinical chemistry and genetics. Her research covers kidney disease, geriatric medicine, neonatal screening, metabolic and endocrine diseases, and biomarkers covering kidney disease, geriatric disease, neonatal screening, biomarkers. Previously at the Catholic Genetic Testing Center at St. Mary’s Hospital, Seoul, Catholic University School of Medicine, South Korea, her interest has since expanded to clinical genetics and molecular genetics, where she explores testing, diagnosis and genetic counseling for congenital diseases. In addition, her current research portfolio includes cancer genetics for precision medicine.
Dr. Jeong-ho Kim He is a professor in the Department of Medicine, School of Medicine (YUCM), Yonsei University, Republic of Korea. He received his PhD in 1983 and later his PhD in 1995 from Yucm. He completed his clinical pathological residency in 1987 at the severance hospital. He has been the director of the Department of Laboratory Medicine in three branches of YUCM, including Jiangnan, Severed and Yangning. His main research interests are the standardization of lipids, analytical factors and therapeutic drug monitoring. His current research focuses specifically on metabolomic studies using mass spectrometry through proteomic analysis to early diagnosis or treatment of therapeutic monitoring of various diseases, such as chronic renal disease, cardiovascular disease, enteropathy and many types of cancer.
