A targeted techniques for treating copper green fake monolithic infections in cystic fibrosis-looking for sugar for sugar
Patients with cystic fibrosis (CF) of hereditary exogenous diseases usually face continuous respiratory infections Copper Green MonococcusEssence The bacteria has the keen ability to adapt and survive in the CF host. Once this colonization is chronic, P. copper green It’s hard to completely eradicate. The bacteria often grow in thick mucus carbohydrates and DNA -rich mucus and the surface of the respiratory tract. Bacteria escapes the host’s immune defense and therapeutic intervention measures. P. copper greenLike other microorganisms, people think that the use of condensate and other carbohydrate binding proteins to attach them to the host and connect to each other in the self -established network. Know how P. copper green The combination with the sugar in the CF airway may provide new therapy clues that restrict these interactions and destroy the successful connection of antibacterial agents for the guidance clues of new treatment.
A recent study provides a new opinion on this opportunity to bind the carbohydrate binding model of this opportunity Copper Green Monococcus This pose a major threat to the life of CF individuals and quality of life. The study was studied by Deborah L. Chance, PHD and Wei Wang (now doctoral degree), Dr. James K. Waters from the University of Missouri, and Professor Thomas P. Mawhinney, as well as Professor Thomas P. Mawhinney and the University of Missouri. Can improve adhesive therapy for continuous infection treatment caused by the bacteria. The study was published in the microorganism journal of peer review.
These colleagues use a multi -price fluorescent glycogen with specific monosaccharides in the Mawhinney Biomedical Research Team to analyze different P. copper green The strains from CF and non -CF sources interact with these carbohydrate structures. Researchers try to determine whether the binding model of these bacteria is based on their phenotype characteristics or separation of their clinical sources. “Our goal is to determine the key sugar that interacts with it Copper Green Monococcus Check whether this interaction is different from the strains between various clinical environments. Dr. Chance said.
Study shows P. copper green The separation strains from CF and non-CF sources all show a significant combination of vertical polymer of the pituitary α-D-D-Dlacta, β-DN-acetylspea, and β-D-lactose-3-sulfate. Adopt advanced microscopy and spectral fluorescent metering technology to introduce cell-level carbohydrate binding models. The team discovered specific confirmation of carbohydrates (α or β) and the presence of specific chemical groups, such as β-DDDDD-lactose -3-sulfate sulfate , Significantly affect the binding affinity of bacteria. In addition, in each positive bacterial culture, a small sub -group has always explained the combination of glycogen polymers of the population.
Interestingly, and P. copper green The specimen shows the shape and physiological activity of various colonies, and the combination of curves seems to be consistent in the entire strain. No structure or other bacterial features can predict more obvious carbohydrate binding behavior. “These discoveries are important, because they show that the phenotype of the strain P. copper green Dr. Chance explained: “Keep a small, continuous sub -group, and be good at related to the very specific sugar.”
this P. copper green The carbohydrate combined survey provides a valuable basis for the design aimed at the design aimed at the treatment of bacterial interaction with the host and biofilm, and may directly target the antibacterial agent to target the organism. Dr. Chance emphasizes the auxiliary treatment potential for or destroying an agent combined with specific monosaccharides P. copper green In the respiratory tract of CF patients, as a tool for the effectiveness of the existing antibiotic therapy, especially in the case of multi -drug resistance to complicate conventional methods.
This study emphasizes the importance of personalized treatment strategies in managing CF. When characteristic heterogeneity is heterogeneous, we enhance our understanding of the interaction of complex carbohydrates P. copper green meet. Dr. Chance pointed out: “A surprising research in studying this very complicated situation is surprising P. copper green The adaptability and survival of the CF host is the sustainability of a specific binding model in various bacterial populations. This indicates that targeted anti -adhesives or anti -microbial treatment may be effective P. copper green The strain, regardless of its diversity of the surface type. “
In short, research by the Mawhinney team marks an important step in the development of targeted therapies for CF -related infections. By using the unique carbohydrate binding curve P. copper greenFuture treatment may more effectively destroy the colonization and persistence of this pathogen, and ultimately improve the quality of life of CF patients.
Journal reference
CHANCE, DL, WANG, W., Waters, JK, Mawhinney, TP “insight Copper Green Monococcus The carbohydrate compounds combined with a multi -price fluorescence polymer with pendant sugar from the cystic fibrosis separation strain are combined. “Microorganism. 2024.Doi: https: //doi.org/10.3390/mitroenismss12040801
About the author
Research on Mawhinney Biomedical Research Laboratory at a glance
Professional knowledge areas: biochemistry, analytical chemistry, carbohydrate chemistry, cystic fibrosis, cancer, microbiology
Specific focus: carbohydrates in cancer and bacterial infections; prevent cancer and treatment; interaction of host pathogenic bodies in cystic fibrosis; analysis methods.
Mawhinney’s research on the research room of the Biomedical Research Laboratory is many interconnected themes. In the field of external secretion defense mechanism, people particularly emphasized the chronic obstructive lung disease of human beings. It has trained quite a lot of efforts to better understand the main and secondary parts of mucin protein as the main and stimulating substances for lung pathogen and stimulating substances. Sexual molecular defense reactions.
Structural clarification has produced significant insights on post -translation modification of the side chain of the breathing adhesive. It proves that the sulfurization of glycoprotein and the significant increase in the anionic ions is similar to the severity and chronic chronic of respiratory diseases, which is particularly obvious among patients called cystic fibrosis.
The ongoing research concentrates the team’s ability and chemical professional knowledge in the structural functional relationship between human and plant health and disease. The internal tools and the core tools of the University of Missouri are allowed to integrate vision, biology, genetic and chemical data in the process of discovery to better understand human health and diseases.
Team member of this research
Doctorate He received a bachelor’s degree in biology at the University of Emory University at Georgia, and then obtained MS and doctoral degrees of biochemistry at the University of Missouri Medical College and Agriculture. Dr. Chose, Dr. Chose, has studied her research on bacterial pathogenesis and cystic fibrosis by Dr. Arnold L. Smith, Chairman of Molecular Microbiology & Symunology, Dr. Chrimine of Missouri. Dr. Chance is currently a professor of part -time assistant research professor of microorganisms and immunology and pediatrics in the University of Missouri Medical College of Columbia. As a research on cystic fibrosis and cancer research, it is part of the Cafnr ESCL interdisciplinary biomedical research team. Dr. Chance emphasizes that the common colonization of cystic fibrosis is the pathogen and its survival strategy among human host. This study aims to help define new treatment strategies for chronic airway infections. Using the basic study of clinical consciousness, patient specimens, analysis, biochemical, molecules, microorganisms, tools, imaging tools are used to generate in vitro Treatment in Huahua. [email protected]
Dr. Wang He received medical training at Shandong University and obtained a PhD in biochemistry in Dr. Mawhinney and Dr. Mawhinney in the University of Missouri, Columbia, Missouri. Dr. Wang continued to be a postdoctoral training at Peking University and was a assistant professor at the University of John, Shanghai. At present, Dr. Wang is an associate professor at the School of Life Sciences of Fudan University. The interface between chemistry and microbiology is introduced. Dr. Wang’s research focuses on formulating new chemical strategies to approach complex bacterial systems that are closely related to human health. [email protected]
Dr. Wats He obtained a doctorate degree in biochemistry from the University of Missouri, Columbia, Missouri. He is currently a chemist and director of analytical services at the agricultural experimental laboratory (ESCL) of Cafnr at Columbia University in Missouri. [email protected]
Dr. Watt’s chromatographic niche market has an analytical interest in the health and nutrition of animals, animals and humans, and Valei V. Mossine Dr. Valei V. Mossine (Water’s chemical synthesis The goal is targeted) multifunctional analysis standards and potential inflammation and useful treatment agents.
Dr. MawhinneyEarly chemical education background included biochemistry training conducted by Fairleight Dickinson University in New York, and then a Demonstrate of Molecular Biology and Forensic Medicine of the United University of New York and the United University of New York. In terms of cystic fibrosis, Dr. Mawhinney Dr. Giulio Barbero, a doctor of medical at the University of Missouri, Ph.D. in Medicine and President of the Department of Pediatrics completed postdoctoral training. At present, Dr. Mawhinney is a professor of biochemistry and pediatrics at the University of Missouri Agriculture, Food and Natural Resources College (Cafnr) and professors at the University of Missouri Medical College of Columbia, Missouri. Dr. Mawhinney also serves as the director of the Chemical Laboratory (ESCL) of the agricultural experimental station (ESCL) of Missouri chemists and the University of Missouri, Missouri. [email protected] is enthusiastic about teaching and research. Dr. Mawhinney continues to be a lifelong learner and educator at the University of Missouri Medical College, as well as the host of global agricultural and medical researchers, through ESCL outsourcing. [email protected]
