Multiple trauma in early life changed the brain of a woman different from that of a man, and we need to pay attention to
Early experiences in life greatly influence and shape the human brain. The vulnerability of neuropsychiatric disorders after life may be due to disruptions in the maturation of the prefrontal cortex (PFC) that is negatively affected by the sensitive developmental period. Some studies have shown that women are more susceptible to early adversity than men.
Kelsea Gildawie, Lilly Ryll, Jessica C. Hexter, Shayna Peterzell, Alissa Valentine, led by Professor Heather Brenhouse of Northeastern University, examines the long-term, gender-specific, gender-specific cumulative effects with mental and mental illness and mental illness. They published their findings in journals Developmental cognitive neuroscience.
They tried to determine how the separation of newborns and caregivers was performed with peers for a second social isolation, which might have a specific complex effect on PFCs, which helped neurons adapt. and grow sugars and proteins, and if so, contribute to anxiety-like behavioral sensitivity. Kelsea Gildawie performed behavioral tests on rats after she was isolated from her mother and later on socially. Later, they used immunohistochemistry, microscopy and image quantification to show the differences to expose differences between individuals.
One of the basic findings of this critical study is that social isolation from peers can be found in women rather than men Reverse Some harmful effects of neonatal adversity on the way animals respond to potential environmental threats; however, neonatal adversity may be when viewing other types of behaviors that indicate anxiety Protect The harmful effects of teenagers on social isolation. When researchers studied the cellular levels of the brain, they found that both adversities have a more complex role for perineal mesh, which help neurons communicate with each other.
Professor Brenhouse explained: “These findings are important because they show that the developing female brains get information from their early life and process them in ways that influence her perception and response to subsequent threats, including The threat of isolation when growing up with peers., and later threats in adulthood. The male brain appears to have different treatments for these same types of trauma and has the potential to cause different types of vulnerability and resilience between the two sexes. “Their Data show that the double hit of adversity has a higher long-term effect on the net structural integrity of peripheral neurons and albumin cell counts in women.
“In the current study, we observed the gender-specific effects of adversity on ADHD and risk assessment behaviors; however, contrary to findings in the brain, the pattern of results is not essentially additive,” Ms. Gildawi said. This may suggest that anxiety-like behavioral changes are not entirely caused by adversity-induced destruction of albumin and perineurons, and that other processes may be threatened. She later added: “Future work will investigate other prefrontal cortex-mediated behaviors that may be altered by neural structure maturation such as social behavior and working memory.”
This new study has great potential to inform scientists and clinicians about the impact of early life adversity, as it points to a significant difference in men and women changing their development when exposed to these stressors. Therefore, we can better understand neuropsychiatric sequelae and may improve preventive treatment.
Journal Reference and Major Image Credit:
Gildawie KR, Ryll LM, Hexter JC, Peterzell S, Valentine AA, Brenhouse HC. Two adversity models in developing rats revealed gender-specific effects on frontal cortex structure and behavior. Dev Cogn Neurosci. April 2021; 48:100924. doi:10.1016/j.dcn.2021.100924. Epub 2021 January 27.
About the Author
Dr. Heather Brenhouse
Associate Professor
Dr. Heather Brenhouse is an associate professor in the Department of Psychology at Northeastern University. She received a bachelor’s degree in psychobiology from Binghamton University, a master’s degree in behavioral and systems neuroscience from Rutgers University, and a doctorate. Doctor of Experimental Psychology from Northeastern University. She worked as a postdoctoral fellow at Harvard Medical School at McLean Hospital and worked as a coach at Harvard Medical School before joining the Northeast in 2012 Behavioral Neuroscience and Psychology in the Northeast in 2012 Learn from teachers.
Kelsea Gildawie, MS
Doctoral candidate
Kelsea Gildawie is a Ph.D. Candidate at Northeastern University, led by Dr. Heather Brenhouse, Development Neuropsychobiology Laboratory. She received her bachelor’s degree in neuroscience and behavior from Simmons University, where she studied the role of nutrition on age-related cognitive decline in mice. Her current research involves the effect of early life adversity on sexually dependent neuroimmunity and neural structure throughout the development and corresponding behavioral disruption process.
