SOLNUL™ study uses microbiome and metabolomic data to link enhanced functions of gut permeability and histamine levels

In the ever-evolving world of nutrition and health, an interesting question arises: What foods we eat not only affect our gut health, but not just provide the necessary nutrients? In particular, can certain types of starch not only resist digestion, but also play a role in managing the histamine levels in our bodies? Histamine, which is often associated with allergic reactions, is also a key player in various gastrointestinal disorders. Interestingly, histamine intolerance stems from not only our diet, but also from the complex world of gut microbials. This interaction between diet, gut health and histamine levels sets the stage for a fascinating study on drug-resistant starch (RPS), a dietary ingredient in the diet that may be much more than Eye.

A pioneering study in the field of nutritional science reveals the health benefits of drug-resistant starch (RPS) supplementation, as published in the Journal of Functional Foods. This study shows that incorporating RPS into a daily diet can significantly reduce serum histamine levels in healthy adults and signal enhances intestinal barrier function.

Together with collaborators at Starch Products Inc., Manitoba, along with collaborators at the University of Victoria, the University of Nebraska, the University of Newfoundland Memorial, the University of Texas and Nutrasource Phartrasirce Pharmaceutical and Nutraceutical Services, the study aims to explore Research on impact impact. Intestinal health of RPS. Participants were divided into two groups and received RPS or placebo daily. The researchers used advanced technologies such as liquid chromatography-mass spectrometry to analyze changes in serum amino acids and other related metabolites.

The results of this study are remarkable. Serum histamine levels were significantly reduced in participants who consumed RPS. This is a positive signal for intestinal health, as histamine is closely related to various gastrointestinal problems. “Seeing this reduction in histamine highlights the potential of RPS in promoting gut health,” Dr. Bushin said. In addition, RPS was found to lower levels of certain bacteria in the gut, which are known to produce histamine.

In addition to reducing histamine levels, RPS also positively affects other metabolites associated with intestinal barrier health. There have been significant changes in specific compounds, suggesting that RP can improve the protective lining of the intestine. These broader findings provide a deeper understanding of how RPS supports overall gut health and complement its known probiotic benefits.

“Our findings raise the interesting possibility that histamine sensitivity may involve impaired intestinal barrier function, amplifying the complexity of the condition while also providing new avenues to alleviate it,” Dr. Bush said.

This study not only contributes to our understanding of gut microbiota and metabolism, but also emphasizes the role of dietary ingredients in maintaining health. As Dr. Bushin explains: “Our study expands the range of RPS as a dietary supplement, showing its impact on key aspects of gut health in healthy adults.” The findings of the study aim to enhance gut health and Dietary supplementation strategies that address histamine-related concerns are promising.

In summary, this study on RPS highlights the therapeutic potential of the supplement, suggesting that regular inclusion of diet may be a simple and effective way to improve gut health and manage histamine levels in healthy individuals.

Diary and image reference:

Bush, Jason R. et al. “Drug-resistant potato starch supplements can reduce serum histamine levels in healthy adults and are associated with intestinal permeability.” Journal of Functional Food 108 (2023): 105740. doi:

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