Imagine a world where the body’s healing process goes beyond the goal, resulting in conditions that not only produce obvious scars, but also force our fingers to curl into the palms and keep them in that position. This situation is not a science fiction story. This is the reality for people with Keloids and Dupuytren diseases. The breasts are thick and have scars growing on wounds, while Dupuytren’s disease causes fingers to bend into the palm, which is due to the thick scar tissue that presents unique challenges for many. Both of these conditions are caused by the body’s recovery process, which leads to excessive scarring not knowing when to stop. Despite how common they are and have a significant impact on people’s lives, effective treatments are elusive and often resort to surgery, which does not always prevent the condition from returning. In this context, scientists have been exploring the genetic roots of these diseases, hoping to discover new ways to treat their sources, rather than just addressing symptoms.
Under the leadership of Dr. Elias Volkmer of the Ludwig Maximilian University in Munich, Germany, including Marcus Stocks, Annika S. Walter, Elif Akova, including Marcus Stocks, Professor Wolfgang Boecker, Attila Aszodi, Gerd Gerd Gerd Gauglitz and Dr. Maximilian Saller, pioneering advances have made progress in decoding the genetic basis of mammary and Duples’ disease. Their study details the Heliyon Journal, using advanced gene sequencing to reveal unique genetic patterns that define these two fibrotic conditions.
Although at first glance, Keloids and Dupuytren’s disease seem to be similar, studies show that they follow completely different genetic pathways. This key finding points out that each condition has its own genetic characteristics, laying the foundation for new therapeutic strategies that go beyond conventional surgical methods.
Elias Volkmer elucidates their findings: “We carefully extracted high-quality genetic material from all tissue samples and found that a large number of genetic behaviors were different, which was statistically significant. . Surprisingly, despite their similar appearance and role, we found that the genetic makeup between the two conditions did not overlap, suggesting that they have completely different genetic characteristics.”
The team started working by collecting an organizational sample of people with any conditions, ensuring that all ethical guidelines are followed and that participants’ informed consent is followed. They then used cutting-edge gene sequencing technology to thoroughly examine the activity of genes throughout the genome. This approach allows them to pinpoint genes that are more or less active in specific genes, thus elucidating unique biological processes and pathways in each case.
Volkmer explained in reflection on their approach: “After tissue genetic data, we align it with human references to find the activity levels of a large number of genes. We then attribute the gene activity levels to the The data is uniform and simplified to better understand the genetic landscape.”
This groundbreaking study not only deepens our understanding of the genetic factors that drive these diseases, but also opens up personalized treatments to address specific genetic abnormalities in each disease. The potential benefits of these findings are enormous, offering new hope for people affected by these often debilitating conditions. Volkmer highlighted the importance of their work: “Our analysis highlights molecular changes in each case. It is worth noting that we found that there is no shared spectrum of genetic activity between them. Our study states Key biological processes and signaling pathways that may play a key role in their development and development.”
Journal Reference
Marcus Stocks, Annika S. 2024. doi: https://doi.org/10.1016/j.heliyon.2023.e23681.
About the Author
Dr. Volkmer He is an outstanding medical expert with an outstanding educational background and began in his hometown of Munich. His academic journey at Ludwig Maximili University (LMU) in Munich was marked by outstanding achievements and ultimately achieved a prestigious allowance that promoted his study at Harvard Medical School in Boston. During her eight-month tenure at the Mayo Clinic in Rochester, Minnesota, Dr. Volkmer’s passion for research was ignited. There, he conducted key experiments for his dissertation in the respected Larry Karnitz research lab, laying the foundation for his future in medical research.
Following this experience in formation, Dr. Volkmer specializes in balancing his research and clinical responsibility. His clinical focus on surgery has made him one of the most famous experts in Munich and southern Germany. Dr. Volkmer recently completed a rigorous professorship at LMU, further demonstrating Volkmer’s commitment to medical knowledge and practice. His career demonstrates his dedication to medical research and clinical aspects, highlighting his important contribution to the medical community.
