The future of changing cancer treatment with advanced technology is approaching quickly. Using innovative strategies to treat nucleic acids indicates that cells are paving the pathway for fundamental molecules that fight diseases such as cancer. The challenge is to pass these molecules in cells, similar to passing secret messages through indestructible walls. This is just a guess, but the essence of the recent breakthrough. Fine, specialized carriers, known as nanoscale metal-organic frameworks (nanopoly), have been developed to transport these key molecules directly to the center of cancer cells, leading to natural defense capabilities that have long been obstacles. In addition to conveying the message, this approach ensures that it reaches the right recipient without the traditional therapeutic side effects. This major advancement will change the battle with cancer, a pioneering moment for gene therapy.
Dr. Gilles Patriarche of Almería also comes from the University of Paris in a groundbreaking study led by Dr. Ruxandra Gref of the University of Paris-Saclay and Dr. Kirill Afonin of the University of Charlotte, University of North Carolina. – University of Saclay and Sandra Arroyo-Becker, Yelixza I. Avila, Dr. Morgan Chandler of the University of North Carolina, and Paris-saclay Dr. Xue Li li of the university revealed new approaches to treat cancer in International Drugs: X, showing the huge potential of nanoscale metal organic frameworks (Nanomofs) in gene therapy. This pioneering study shows how nanopopulation delivers therapeutic nucleic acids directly to cancer cells, thus opening new doors in the fight against this widespread disease.
The method uses engineered nanoF packaging and sends therapeutic nucleic acids to cancer cells. This faces a major challenge in gene therapy: obtaining negatively charged nucleic acids through cell membranes. These carefully designed nanopopulations not only overcome this obstacle, but can also target specific cancer cells, thereby improving the effectiveness of the treatment.
Dr. Afonin elucidates their findings: “We have successfully utilized engineered nanoFs developed by the Ruxandra Gref team to deliver therapeutic nucleic acids to cancer cells, demonstrating the reported MDA-MB-231 breast cancer expression The significant reduction in reporting expression demonstrates this point that cells interfere through RNA. “This breakthrough can open the door to more effective cancer treatment by delivering genetic material directly into tumor cells.
The team adopted a complex approach to developing and evaluating nanopopulations, starting with the use of ferric chloride and benzene 1,3,5-tricyclic carboxylic acids using microwave-assisted processes. Subsequent modifications can more effectively enhance the targeting of the surface of nanoF to cancer cells, especially by introducing P-CD-M to enhance cell affinity. Preparing nucleic acids for integration into nanopopulation is a detailed step involving multiple optimization schemes to achieve optimal protection of nucleic acid cargo and maintain its integrity, thus ensuring their effectiveness at delivery. Their appropriate size, stability and successful nucleic acid loading are confirmed through the characterization of dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA), thus verifying their potential for real-world applications.
Several tests were conducted to verify the effectiveness of nanosomes, including studying the extent to which cells absorb nanopopulation and their ability to silence specific genes. These tests show that nanopopulations are effective in entering cancer cells and providing their nucleic acid carbon, resulting in the desired therapeutic effect.
The implications of this study are important and provide promising new avenues for cancer treatment. By allowing precise delivery of therapeutic nucleic acids to tumor cells, nanopopulation has improved the accuracy and efficiency of gene therapy, minimizing side effects and improving patient outcomes. Dr. Afonin’s highlight, “combining different therapeutic agents will produce a more obvious therapeutic effect”, highlighting the potential for using nanopopulation in combination therapy for better results.
This innovative work lays the foundation for further exploration and development of nano-based therapies. More comprehensive structural functional studies are needed to expand the current platform, indicating the future direction of this exciting field of research. The successful application of nanopopulation in gene therapy can transform cancer treatment and provide new hope for millions of patients around the world. In summary, research by Dr. Gref and Dr. Afonin shows that nanoF provides new avenues for cancer treatment, effectively delivering nucleic acid therapy to targeted cells and enhancing therapeutic efficacy. Their study confirms the protection and delivery capabilities of naminov, emphasizing the potential of innovative, less invasive treatments.
Journal Reference
X. Li et al., “Nanoscale metal-organic framework for delivery of nucleic acids to cancer cells”, International Journal of Pharmaceuticals: X 5 (2023) 100161. DOI:
