According to a new study from the University of Boston University of Medicine, a local treatment method to remove aging cells can change the way for the elderly to recover from surgery and cure wounds. This study was published in aging on December 3, 2024, indicating that a drug called ABT-263 can significantly improve the wound healing of elderly skin and directly applied to the surface.
These findings may have a significant impact on elderly patients, and they often struggle in slow wounds and surgical rehabilitation. By targeting and eliminating aging cells (cumulative cells accumulated with age), the treatment can be healed by 80 % of the treatment of elderly mice within 24 days, while unb treatment mice are only 56 %.
Researchers pointed out in the papers: “Our research emphasizes the healing of wounds of skin aging to enhance the potential of local plug -in -soluble therapy, thereby putting forward the potential and hopeful strategies of preoperative care.”
The research team was led by Daniel S. Roh at Daniel S. Roh from the University of Boston Aram V. Chobanian and Edward Avedisian Medical College. It applied ABT-263 to the skin of a 24-month-old mouse. Wounds before test healing reactions.
New method of skin regeneration
What makes this study particularly interesting is the working principle of the drug. ABT-263 belongs to a category of drugs called nasal solvents. These drugs are targeted and removed aging cells accumulated in aging tissues. Although these damaged cells no longer work, they will resist natural death and damage the human body’s repair mechanism.
This treatment triggered a short -term inflammation response, which is surprising that it seems to be beneficial. This controllable inflammation raises specific immune cells called skin macrophages, which may “start” tissue to improve healing. The drug also activates multiple genes involving wound repair, including the genes responsible for producing new blood vessels and those genes that produce collagen, that is, the key component of the skin regeneration.
A targeted therapy can minimize side effects
It is important that local application methods seem to avoid common side effects related to oral nasal solvents. Researchers have found that ABT-263 only affects aging tissues containing accumulated aging cells and has no significant impact on mice.
This selective effect shows that this treatment may be particularly valuable for elderly patients who are preparing for surgery. The study shows that pre-processing skin pre-treatment with ABT-263 may be healing the surgical wound, which may reduce complications and recovery time to create more favorable conditions.
The meaning of the future
Although these results are hopeful, researchers emphasized that more research needs to be conducted before human beings testing for treatment. This research has opened up new possibilities to solve the difficulty of rehabilitation with age, especially with the growth of the global population, especially related.
This study was supported by the National Institute of Aging and Boston Claude D. Pepper’s Independent Center, emphasizing its importance in the field of medical research related to age.
With the continuous aging of the global population, finding effective treatment for slow wounds becomes more and more important. This research represents an important step in responding to the increasing medical challenge, which provides hope for improving the rehabilitation results of elderly patients.
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