SSP reduces the external seepage of immune cells to psoriasis leather in mice skin.
The restoration of peripheral immune tolerance and preventing destructive autoimmune reactions are the key functions of the immune system, and the dendritic cells (DCS) plays a key role. DC not only initiated an immune response to the pathogen, but also has immune tolerance for self -antigen. The continuous imbalance of peripheral immune tolerance is related to the onset of autoimmune diseases. Therefore, re -activating the human body’s own mechanism to restore interferebing immune balance seems to be an ideal way to prevent the development of autoimmune diseases.
Researchers from Westfaelische Wilhelms-UNIVERSITY from Muenster have made great progress in understanding the natural regulation of spleen’s immune tolerance. Their discovery shows that the subset of the small spleen peptide (SSP) affects the differentiation of dendritic cells by regulating extracellular ATP synthesis. Dr. Viktor Wixler and Rafael Dantas, Dr. Georg Varga, Dr. Yvonne Boergeling and Stephen Professor Stephan Ludwig collaborated, this pioneering research has been published in the “Biomolen” magazine.
The group’s research shows that SSP has the important potential of restoring peripheral immune tolerance, which is the key to managing autoimmune diseases. Dr. Wixler said: “Our previous studies showed that even in the case of continuous high levels of inflammatory cytokines TNFα, small spleen peptides can effectively prevent the development of psoriasis arthritis that have been established. In addition, Our research shows that the DC, which is important in maintaining immune balance, is mainly affected by SSP and converted into tolerance cells, thereby promoting the development of immunosupply
In recent studies, researchers identified thymine as the main component of SSP, and thymine β4 (Tβ4) appeared as the most common peptide. Interestingly, compared with the natural SSP mixture, restructuring thymine in suppressing arthritis is less efficient. The team assumes that SSP regulates extracellular ATP (EXATP) overview. The real -time survey revealed that the tolerance stimulus of SSP caused Novo Novo EXATP synthesis and then significantly degraded, while immunogenic stimulation caused significantly increased and degradable EXATP.
The discovery of the EXATP section is essential for determining the fate of DC to inflammation or tolerance. In this case, the importance is ATP degradation of adenosine, which is recognized as the key tolerance stimulus. Consistent with this and the anti -inflammatory effect of SSP’s body, the team’s research shows that the tolerance characteristics of SSP are mainly affected by adenosine receptors. In addition, the administration of SSP in the body is proven to inhibit the inflammation of psoriasis, and further emphasizes its treatment potential. Dr. Wixler emphasizes: “The activation of adenosine receptors significantly affects gene transcription, and regulates various cell processes, including vascular tension, tissue damage and repair, and neuritis reactions and inflammation.”
All in all, the research of Dr. Wixler and his colleagues emphasizes the importance of SSP as a natural regulator for peripheral immune tolerance. Their discovery provides the basic insights of the dendritic cell differentiation by regulating extracellular ATP synthesis, and paving the way for new treatment strategies for the treatment of autoimmune diseases.
Journal reference
Wixler, V. ; Leite Dantas, R. ; Varga, g. ; Y. Ludwig, s. Small spleen peptide (SSP) forms a dendritic cell differentiation by regulating an extracellular ATP synthetic spectrum. Biomolecular 2024, 14, 469. Doi: https: //doi.org/10.3390/biom14040469
About the author
Dr. Viktor Wixler He studied for a biological degree and received a doctorate in Norwasibillesk in Russia. His career brought him to various scientific institutions around the world, from the well -known laboratory from the famous laboratory to Asia, the United States and Europe. During his academic journey, his main focus was on tumor immunology, autoimmune diseases and molecular cell biology. Over the past two decades, he has been an associate professor at the University of Mustere in Germany. Since the official retirement four years ago, he re -ignited his enthusiasm for work in hand -to -hand laboratory, and lived on his bench, and often worked independently. This re -discovered old commitment is also a catalyst for creating this article.
