By discovering a new method of secureing muscle cells to safely stimulate muscle cells, the potential of muscle against cancer has achieved a significant leap. This novel method is designed to use the natural secretion of muscle cells, and these muscle cells have been found to contain strong anti -cancer characteristics. By using these secretions, researchers hope to formulate a non -invasive strategy to reduce the growth and invasion of cancer cells, especially in breast cancer.
This pioneering research, which was led by Professor Alfredo Franco-Obregón and Dr. Yee Kit Tai, at the National University of Singapore. The research team shows that a 10 -minute low -energy PEMF may induce muscle cells to release the secretion group with effective anti -cancer characteristics. The study further emphasizes the key role of high temperature demand A1 (HTRA1), which is proven to be necessary and is enough to accommodate the anti -cancer effect observed. Professor Franco-Obregón pointed out: “The magnetic stimulation of muscle cells in the secretion group is significantly enhanced by the ability of muscle cells in the secretion group to inhibit tumor growth and blood vessels.”
In the experiment, the conditioning medium of muscle cells exposed from PEMF reduced the proliferation and invasion of several breast cancer cell lines, including MCF-7 and more malignant MDA-MB-231 human breast cancer cell lines. When mammary tumors are implanted with breast cancer on eggs, the PEMF condition medium will significantly reduce the size of microma and reduce the formation of new blood vessels, otherwise it will support the growth of tumors. Dr. TAI explained: “Our results show that the secretion group produced by magnetic stimulating muscle cells can effectively target and reduce the growth of cancer cells and spread.”
A amazing aspect of this study is that the adaptability and effectiveness of the secretion group is repeatedly exposed after PEMF. By pre -processing the muscle cells generated by PCM generated by PEMF in tissue culture, researchers can stimulate the reaction of the anti -cancer secretion group of muscle cells in vitro and in vivoEssence “This pre -processing paradigm shows a novel in vitro Reappear exercise to adapt to skeletal muscles to form a method of anti -cancer factors, but now, in the isolated cultivation of muscle cells, anti -cancer factors produced by cleaning are used for treatment and exploitation. In addition, when our magnetic treatment platform is used in the context of cancer patients, it may enhance the human body’s natural anti -cancer defense measures, but similar to exercise, but it does not require severe exercise. This may be for many cancer patients. It may be for many cancer patients. Inconsciously, “Franco-Obregón added.
The two -headed laboratory research team also explored the potential mechanism of anti -cancer effects observed. They have determined HTRA1 as key participants who media for these effects, because the increase in PCM is critical to reduce the vitality of cancer cells. The study further shows that reorganizing HTRA1 can mimic the anti -cancer characteristics of PCM, and the HTRA1 exhaustion of the PEMF condition medium consumes these effects. Dr. TAI said: “The role of HTRA1 in this process is crucial and highlights its potential for treating targets.”
These provocations in vitro and Prelude The results were verified among mice. The result should be exercised (twice a week) or giving magnetic stimulation (10 minutes per week) for 8 weeks. It shows that the two groups of mice inhibit the growth and invasion of breast cancer cells, and have increased compared to the HTRA1 level of the control mice, while the level of HTRA1 has risen, but the control mice have not performed magnetic treatment.
The meaning of this study is indeed profound, providing promising non -invasive strategies for the use of cancer treatment of muscle secretion group. These discoveries may be paved with new clinical applications, especially for patients who cannot participate in regular physical exercise. Professor Franco-Obregón concluded: “Our research has opened up new cancer treatment pathways through safe release and natural biological active agents released by muscle cells, thereby providing novel methods for preventing cancer and management.”
Journal reference
Thai, YK, Iversen, Jn, Chan, KKW, FONG, CHH, ABDul Razar, RB, Ramanan, S., YAP, LYJ, Yin, JN, TOH, SJ, Wong, CJK, CJK, CJK, CJK, CJK Koh Peach, Koh Pea, Huang Pea, Huang Ryj, Franco-LYJ, Franco-LYJ, Franco-Obregóna (2024). The secretion of magnetic stimulating muscles shows the effect of anti -cancer: the new pre -treatment method highlights the role of HTRA1. Cells, 13,460. Doi: https: //doi.org/10.3390/cells13050460
Wong CJK, TAI YK, Jasmine Lye Yee Yap, Fong ChH, LOO LSW, Kukumberg M, FRöHlichj, ZHANG S, Jing Ze Li, WANG JW, Rufaihah AJ, Franco -obregóna (20222). The pulse electromagnetic field that is briefly exposed to the directional specificity can stimulate the release of the extracellular vesicles and antagonomy through the splinycin: potential regeneration medicine and food industry paradigm. Bio -material, 287, 121658.doi: https: //doi.org/10.1016/j.biomaterials.2022.121658
About the author
connect Alfredo Franco-Obregón From the perspective of biological physics, it is close to organizational engineering and regeneration, and is used as a replacement method for traditional pharmacological intervention measures. He is particularly interested in how the electromagnetic and mechanical power drives the organization. Professor Alfredo Franco-Obregón is responsible for the binary muscle laboratory (biological ion current electromagnetic pulse system). Under the joint host of the surgical department, IHEALTHTECH (NUS) National University (NUS) IHEALTHTECH NUS) (NUS) is actively studying how to carry out magnetic magnetic fields to promote mitochondrial respiratory and downstream development and survival adaptation by the process of being called magnetic with silk bodies. The key areas he are interested in are skeletal muscle development, stem cell biology and cancer, and are ideological leaders and innovators who are used to organize engineering and renewable electromagnetic and mechanical forces. Clinical application.
Personal information of the National University of Singapore:
TAI Yee Kit He obtained a doctorate degree in Singapore National University (NUS). In 2016, he joined the two -headed laboratory as the chief scientist. Dr. TAI cooperates with the skilled scientist team. It is key to develop and verify the development and verification of cutting -edge magnetic equipment designed to activate skeletal muscles. This pioneering research shows that it has mobilized beneficial factors from muscles, which significantly promotes our understanding of muscle physiology and treatment. In addition, Dr. TAI’s work reveals the significant effectiveness of the electromagnetic field in stimulating the specific category cationic channel, which brings the opportunity to change the type of cancer type that targets these magnetic field sensitive channels. This discovery has the potential to completely change cancer treatment and provides new ways for targeted therapies. Dr. TAI’s contribution to electromagnetic, cancer and regeneration medicine emphasizes his dedication to promote medical innovation and improve patient care.
Personal information of the National University of Singapore:
Learn more information about the two -headed laboratory (electromagnetic pulse system) here:
