Aging has been troubled by scientists for a long time because it involves the gradual decline in our cells and tissue working methods. Researchers Professor Gert Schmid-Schönbein and Professor Frank Delano from the University of California San Diego put forward a surprising explanation on aging: the human body may hurt itself through digestive enzymes. Their important discoveries shared in the magazine of “PLOS ONE”.
Studies have shown that enzymes usually retained in the digestive system are leaked to other parts of the human body because the protective barrier in the intestine weakens with age. This obstacle in the small intestine usually prevents these powerful enzymes from spreading. Each meal will damage the obstacles and no longer recover. With the gradual disappearance of this protection, enzymes such as ispase, elastase, lipase, and amylase began to be constructed in important organs such as liver, brain, skin, and heart. The accumulation is related to tissue damage, including the decomposition of collagen and damage to insulin receptors, which are common signs of aging.
Professor Schmid-Schmnbein said: “Our discovery shows that the natural digestion process may accidentally cause tissue damage.” “When these enzymes escape the intestines, they may attack the human body’s own tissue, cause chronic inflammation and destroy basic functions.”
Through the test of young rats and mice, researchers provide strong evidence to support their ideas. Older rats show these enzymes in different organs, causing obvious harm in these organs. For example, is found to be found between cells, which causes severe damage to collagen, thereby giving tissue structure. The study also found that a specific enzyme resistant stagnator for rats, Transxamic Acid, reduced enzyme leakage, enhanced intestinal walls and helped protect the tissue.
Professor Delano pointed out: “High glucose levels of mice are related to the decomposition of insulin receptors on the surface of cells.” They explained that enzyme activity may interfere with how the human body controls the level of sugar, thereby highlighting the broader impact of these leaks.
These findings reveal an unexpected turning point: enzymes that are vital to digestion may also cause aging by attacking the body itself. The team’s research provides new possibilities for the treatment that can slow down to slow down. Professor Schmid-Schmnbein commented: “This discovery has changed our views on aging and opened potential strategies to prevent its influence.”
Researchers brought together their results, and suggested that this self -digestion process may explain many health problems related to age, such as diabetes and heart disease. By paying attention to reducing enzyme leakage, this study pointed out a new method of maintaining tissue health and slowing aging process.
Journal reference
Delano Fa, Schmid-SCHönbeingw “Automatic Digestion”. PLOS. 2024; 19 (10): E0312149. Doi: https: //doi.org/10.1371/journal.pone.0312149
About the author
Gert W.SCHMID-SCHönbein It is an outstanding professor and former chairman of the Department of Biological Engineering at the University of California (UCSD). He teaches biomechanics of biological tissue, microcirculation, lymphology, biology, and cells and molecular biomechanics, and applies it to human diseases. Schmid-Schmnbein is the chairman of the Micro Circular Society. The Biomedical Engineering Society is a consultant to the National Institute of Health, the founding member of the Institute of American Medical and Biological Engineering, and the chairman of the Biomechanical Council of the World.
His team’s current research focuses on answering a basic question: What is the trigger mechanism of inflammation caused by multiple tissue injuries and organ dysfunction? His team discovered a mechanism due to pancreatic digestive enzymes that specified it as “automatic digestion”. This is due to the leakage of the gastrointestinal and surrounding organs from the gastrointestinal and intestines. The team provides evidence that the cell dysfunction of X metabolic syndrome is due to the unbelievable activity leaked from the gastrointestinal tract from the gastrointestinal tract. The digestive enzyme activates the two -stage protease and causes the cracking of the extracellular domain of the membrane receptor. For example, in addition to many other cell dysfunction, Insulin resistance Due to the cracking or Smooth blood vessels sparsely Due to the cracking of endothelial growth factor receptor and endothelial apoptosis. In addition, the group showed acute bleeding and sewage shock, and the high concentration of pancreatic digestive enzymes emitted from the gastrointestinal tract, causing severe cell dysfunction, leading to complete organ failure. The group shows that the internal intestinal obstruction of the pancreatic digestive enzyme can reduce the dysfunction of acute organ and reduce the incidence. Schmid-Schmnbein proposes that automatic digestion may be the basic mechanism of aging, disease and death.
Professor Frank Draino: My philosophy is to understand the basic mechanism of disease at the level of microvascular levels, rather than treating diseases. As a biological engineer, I have applied physics and engineering principles to biomedicine to create new knowledge, and use this knowledge to understand human diseases and improve medical care. I have used research to transform these knowledge from the bench to the edge of the bed. It is important to use drugs to treat diseases, but it is more important to understand the microvascular mechanism that fails to fail when tissue or organs illness. The spirit of dedication and hard work best describes my work habits. The success of my research efforts is because of difficulties or failures, I have never given up the research project. My enthusiasm for microcirculation is obvious, because I have been in the microcirculation laboratory (University of California, University of California, St. Diego) for nearly 50 years. I have made pioneering contributions to various fields, including hypertension, shock (sepsis, bleeding) and development to understand human diseases and improve medical care. To. I have maintained long -term cooperation with other research laboratories and won two microcirculation awards with prestige. In 1980, I won the Malphigi Gold Medal in 1994, the European Micro Circle Association and Lafon Award, and the European Microcirculation Association. Medical science). I am the author of many manuscripts and awarded a number of patents for me to treat the impact and development of type 2 diabetes and the development of technology (breathing analysis) to diagnose the shock. My current research is to understand how digestive enzymes are relieved from the intestines, and how to minimize the leakage of digestive enzymes and maintain the mucosal layer in the small intestine. Because digestive enzymes cannot distinguish tissue from food, they decompose collagen and destroy many receptors on the cell membrane, such as insulin receptors that cause type 2 diabetes. In the recent manuscript, it is particularly interested in observing the level of aspasinase in the brain and skin in the brain and skin of the elderly, and to prevent the protease inhibitors into drinking water. There are many consequences of this study. Over time, many diseases and diseases are partly related to the leakage of digestive enzyme -related diseases. Minemark (neuron destruction) and skin wrinkles (collagen degradation) is the main candidate of our basic assumptions.
