Due to the advancement of optical genetics, the visual recovery of individuals affected by retinal degeneration has achieved inspiring leap. ResearcherS Dr. Himanshu Bansal and Gur Pyari, LED BY Professor Sukhdev Roy From the Daybagh Educational Institute, Agra, India, have Conducted A Detail Eoretical Study Showing How Light-Sensitive Proteins Called Channelrhodsins, Whig Act as Light Detectors in Cells, Especially Chrmine, The new type of red shift OPSIN and its specially designed variants can help restore vision under environmental lighting conditions. The research published in the “Science Report” provides visual recovery of visual recovery of no bulky goggles, making it easier for millions of people to live.
The study checked the challenge of using optical genetics to restore vision. This technology uses photoretin protein to activate nerve cells in the retina, which is the light -sensitive tissue layer on the back of the eyes. The problems faced by traditional methods, for example, require very bright light, only work within a limited light -colored range, and the response to the change of light is too slow. In the 2021 “Natural Medicine” magazine reported the first successful human clinical trial of optical synthalology therapy for blind patients. Visual functions can re -rotate the real -time retina with a specially designed goggles, and use ChrimsonR Opsin to trigger the retinal ganglion cells guided by photogenic spinning. This study marks major improvements, and highlights how CHRMINE, which has improvement of light sensitivity and robustness, effectively play a effect in daily lighting (such as sunlight and white light) method. This breakthrough marks the process more naturally with users.
One of the most striking discoveries is that Chrmine can activate the ability of nerve cells at a very low level of light, that is, the least amount of light required. These levels are far lower than the brightness of cloudy days. This means that the use of Chrmine devices can work without additional artificial lighting, which is usually not convenient and uncomfortable. Professor Roy pointed out: “This marks a major change in optical genetics, because we can now be committed to integrating natural light conditions into devices that help restore vision.”
Researchers have also studied the improved Chrmine version, including HSCHRMINE, which is a faster variant called a high -speed chromium -plated mutant. The response of this version is faster and can work within a wider light -colored range. Although Chrmine can stimulate the transmitting signal of neuronal cells, that is, the message sent by neurons is similar to the speed similar to the natural process, but high -speed variants can quickly execute twice the speed, thereby improving the quality of visual recovery. These functions are essential for helping individuals’ ability to clearly see color and movement.
The simulation of this study also shows that compared with the narrow light belt (such as the light emitting diode), the light with wavelength (such as the color found in the natural sun, such as the light found in the natural sunlight), this will produce significant significant significantness. Benefits, these diode will produce. Light of specific colors. Chrmine has a stronger response to this type of hybrid light, which responds several times compared to other methods. Professor Roy explained: “The use of light that spans a wider color is a major progress. It can help us achieve high -quality vision recovery and use lower light levels at the same time, so that the eyes are avoided with the safety of heating and light damage damage. , And reduce dependence on artificial lighting. “” “.”
All in all, Professor Roy’s research not only emphasizes the potential of visual recovery without invasion surgery, but also means that there is no need to perform large -scale operations, but it also pointed out that the possibility of the future development of optical genetics is possibly possible sex. By high sensitivity to light intensity and color, rapid response, improvement of quality, and the ability to use natural lighting, Chrmine and its improved version can change the treatment of people with vision loss. These discoveries represent an important step in creating a burden and effective reticulum prosthesis to improve the quality of life of visual disabilities.
Journal reference
Himanshu Bansal, Gur Pyari and SukhDev Roy, “Theoretical prediction of broadband environmental optical visual recovery with Chrmine and its mutant.” Scientific report, 2024. Doi: https: //doi.org/10.1038/s41598-024-62558-2
About the author
Professor Sukhdev Roy He received a bachelor’s degree (honor) in 1986. In 1988, the master’s degree in physics and doctoral degree from the Dayalbagh Education Institute (DEI) in Agrah, India. In 1993, he is currently a professor and person in charge of the Department of Physics and Computer Science, India, India. He has ben a visiting propessor at Harvard, Waterloo, Würzburg, Regensburg, MPI for the Science of Light At Erlangen, Osaka, City University and Queen Mary University of London, and An Associate of the International Center for theoretical Physics, Trieste, Trieste Italy. He won the Young Teacher Award at the AICTE Vocational Award in 2001. JSPS invited scholarships. In Japan in 2004, HC Shah Research Donation Award, Sardar PatelSity of Sardar Patels won in 2006.British stone IETE BB Sen Commemorative Award 2007, IETE-CONF. IETE-M in 2012. The Rathore Memorial Awards, in 2016, the national system gold medal of the Indian system in 2016 and the DEI Outstanding Alumni Award were in 2021. He also won eight international and national conferences. He published more than 200 research papers in well -known journals and conference records, 11 chapters, and had six design patents about drone technology. He hosted 8TH The World Conference and Nano Science and Nano Technology Expo, 2020, Philadelphia, USA. It was an invitation spokesman for the 2008 Annual Meeting of the American Institute of Physics. Members of IEEE, the National Academy of Sciences of the Indian Academy of Sciences, India, IETE (India), SPIE and Optica, and outstanding researchers from the Indian Optical Society.
Dr. Himanshu Bansal I received B SC. In 2015, a master’s degree in BR Ambedkar University, India’s Ambedkar University. In 2017 and 2023, he obtained physics and doctoral degrees from the Dayalbagh Education Institute in Aeyalbagh, India. He won the Young Scientist Award of the Indian Science Conference Association in 2023, the best doctoral dissertation awardTH IEEE International’s international seminar on the progress of IIIT Alahabad Optical Scholarship, in 2023, won two best paper awards at the International Optical Conference and the DSt -Inspire Scholarship in 2012-2022. He is currently a research assistant at the Star Science Center of the Institute of Science in the Institute of Science.
Gur Pyari (Gur Pyari) Reasons for physics and master’s degrees. Physics from the Dayalbagh Education Institute from Agra, India was in 2016 and 2018, respectively. She is a researcher at the Department of Physics and Computer Science, India’s Agra DEI DEI. She won the Best Paper Award on the 6thTH IEEE International Photonics Progress (Wrap) in IIIT ALLAHABAD, 2023. She was a researcher at UGC -SAP from 2018-2022, and received the primary and senior research scholarships of the Ministry of Science and Technology, which was obtained by the Department of Science and Technology. India, 2022-25.
