Oxidation stress, this is a harmful process that can speed up the aging and cause diseases such as cancer, heart problems, and brain diseases, which have always been the focus of many scientific research. This process will occur when the unstable molecules called free radicals overwhelm human defense, which causes this process when cell damage is caused. Now, researchers have made major breakthroughs in creating outstanding new compounds. This kind of compound called plane berdin and Trolox combines the enhanced role of chantin found in green tea and apples. Famous Trolox. The study was led by Professor Kiyoshi Fukuhara and Dr. Ikuo Nakanishi. He recently shared this study in the “Antioxidant” magazine.
Professor Fahara of Showa University aims to protect the body’s damage caused by oxidation pressure. Professor Fukuhara explained: “This compound not only improves the benefits of its ingredients, but also introduces a new method to enhance the defense ability of human body defense oxidation damage.”
These findings are impressive. Compared with separate catechins or Trolox, new compounds are more effective in neutralizing harmful molecules (called free radicals). Free radicals are reactive molecules. Even if they are not checked, they may damage important parts of cells, such as DNA and protein. The working principle of this compound is the same as Trolox, which can prevent the type of damage that causes the cells of cells. This is a gradual loss of cell function over time. These characteristics make it a promising tool to resist diseases related to oxidation stress.
The reason why this compound is unique is how it combines the advantages of its two components. Catex is a natural antioxidant, which means that it can protect the body by stopping the harmful effects of free radicals. At the same time, Trolox is a form of water -soluble vitamin E. It is famous for protecting fat from damage to the cell membrane. By connecting the two, researchers created a compound with stronger protection. “The interaction between the two parts of the compound has formed a network that significantly enhances its antioxidant capacity,” Dr. Nakanishi of the National Institute of Quantum Science and Technology.
This compound is particularly good at targeted active oxygen, which is a specific type of free radicals that especially damage cells and DNA. Active oxygen is a by -product of normal cell process, but it will cause damage when its level is too high. Compared with the use of lava or Trolox, the new compounds are more effective in preventing these harmful molecules. Professor Fahara said: “Our discovery shows that this compound can make significant improvements in the therapy aimed at preventing oxidative damage.”
Next, Fukuhara and his colleagues plan to test this compound in cell and animal research to confirm its effectiveness in the life system. These studies are designed to imitate the role of the compound in the complex environment of living organisms. They also hope to explore the possibility of combining balanced bepenin and other antioxidants (such as Lipoic Acid), such as lipoic acid, which is another substance that is known for its protection of oxidation stress to develop more. Powerful protective compounds.
With powerful harmful molecules and its extensive use, the combination of plane catechins and Trolox marks the main progress of antioxidant science. Antioxidant is a substance that helps to prevent or slow down the damage caused by free radicals. This discovery may lead to better strategies to prevent diseases related to oxidative pressure and improve overall health.
Journal reference
Shimizu, W., Shoji, Y., Ohkubo, K., ITO, H., Nakanishi, I. And fukuhara, K. “Antioxidant activity combined with plane catechins and Trolox.” Antioxidants, 2024. Doi: https: //doi.org/10.3390/antiox13101165
About the author
Kiyoshi Fukuhara He is a professor at the Department of Organic and Pharmaceutical Chemistry of Star University. He obtained a doctorate degree at the University of Tokyo, and later served as a visiting researcher under the guidance of Dr. Hecht at the Department of Chemistry at the University of Virginia.
Dr. Fukuhara has been actively engaged in chemical research chemical research on chemical research, clarifying the mechanism behind various environmental chemicals that helps cancer. He focused on the participation of active oxygen (ROS) in chemical toxicity and discovered the toxic effect caused by many chemicals. His work has expanded to the development of new antioxidant compounds that inhibit oxidative stress, providing hopeful strategies for preventing and treating diseases related to oxidation damage. One of his remarkable achievements includes the three -dimensional structure of stable catechin and other polyphenols. This method can significantly enhance the function of natural antioxidants (such as catechins). At present, Dr. Fukuhara is adopting this method to develop potential candidate drug compounds, further promoting drug innovation.
Ikuo Nakanishi He received his doctorate degree in 1999. Under the supervision of Professor Shunichi Fukuzumi, the University of Osaka University. After serving as POSDOC in the Institute of Health Sciences (NIHS) of Osaka University and National Health Sciences (NIHS), he became a researcher at the Institute of Radi Science (NiHS) Researcher Quantum Science and Technology (QST) (QST) (former National Institute of Radi Sciences) in 2002. Essence IQLS), QST, in 2021. He studied the mechanism of free radical scan reactions using antioxidants using physical chemical technology, such as stopping flow, electronic magnetic resonance and resonance (EPR), ring -shaped ambush method, etc. Based on mechanical insight, he designed a new type of synthetic antioxidant. Compared with natural antioxidants, it has higher free radical antioxidants with natural antioxidants and cooperates with Professor Fusheng.
