According to the type of cancer, the key protein that is beneficial or harmful to cancer patients is beneficial or harmful
Scientists at the University of Rondrin Mani, a professor of Katrin Mani, discovered the complexity of specific proteins participating in cancer growth, and sometimes even contradictory. Their research was published in the “International Molecular Science Journal” and explored how this protein (referred to as GlyPican-4) affects the development of cancer based on the type of cancer. Studies have shown that GlyPican-4 can be used as a symbol of the prediction results and can also be used as a potential goal of new cancer treatment.
GlyPican-4 is part of a set of protein. They play a vital role in how cells communicate with each other, which is important for cancer development. The research team analyzed the manifestation of the protein in various types of cancer by checking a large cancer database called a large cancer database called the Cancer Genometer. Their discovery shows that the activity level of the protein has changed significantly according to the type of cancer, and high levels and low levels are related to cancer progress in different situations.
For example, the study shows that Glypican-4 is more active in a gumocytoma of a brain cancer, while Glioblastoma-4 is more active in bile duct cancer (cancer of cholanges). In these cases, the high activity of protein is related to the poor prognosis of patients. Instead, in non-small cell lung adenocarcinoma, a common type of lung cancer, a higher GlyPican-4 level is related to a better survival rate. The important contributions of VictorchéRouvrierhansson have adopted advanced gene editing techniques to stop protein in the cells of gum female celloma and lung adenocarcinoma. Their discovery shows that turning off GlyPican-4 reduces the growth of glue parent cell tumor cells, and surprisingly accelerates the growth of lung adenocarcinoma cells.
Professor MANI emphasized the importance of these discoveries, and pointed out: “Our discovery shows that the increase in GlyPican-4 levels is related to the poor prognosis of glue female cytoma, which also shows that the results of patients with lung cancer are favorable.” This is prominent GlyPican-4’s dual effects in cancer, in some cases, it promotes the growth of cancer, and in other cases, it seems to inhibit cancer.
In order to understand these influences, researchers have studied how GlyPican-4 affects the activity of various genes that work in cancer. In glue female celloma, the protein seems to enhance the activity of genes that help cancer cells grow and survive, including genes that participate in key signal pathways that promote the progress of cancer. However, Glypican-4 seems to have the opposite effect in lung adenocarcinoma, which reduces the activity of these same ways, which is consistent with the better results observed in patients with high protein.
In the article, it is pointed out: “The survival analysis of the data of patients with TCGA cancer reveals the different role of GlyPican-4 in various cancer types.” This indicates that the function of the protein depends on the type of cancer, and its impact may have a great impact.
Researchers believe that the different effects of GlyPican-4 in various cancers may be related to the way of interaction between the tumor environment, and there may be a large difference between the type of cancer. Professor MANI pointed out that although the various functions of the protein make it a promising sign of cancer, they also emphasize the need for the treatment strategies tailored by each specific type of cancer.
The discovery of the study paved the way for future research to develop treatment methods for GlyPican-4 in a way for cancer types. By understanding why GlyPican-4 has different behaviors in different cancers, scientists can develop more effective and personalized treatment strategies for patients.
Journal reference
Chérouvrierhanson, V., Cheng, F., Georgolopoulos, G. , & Mani, k. (2024). “GlyPican-4 is a dual-point method for cancer progress and its bingling with cancer genes.” International Molecular Science Magazine, 25 (3945). Doi: https: //doi.org/10.3390/ijms25073945
About the author
Katrin Mani (Katrin Mani) It is a well -known professor at Lund University, where she obtained a doctorate degree in medical and doctorate. Her research is concentrated in the role of protein glycogen in health and disease, and pays special attention to cancer and neurodegenerative diseases. Professor MANI made significant contributions to the beginning of how the protein polysaccharides affect these conditions. Her works are published in the leading scientific journals, reflecting her commitment to promote biomedical research and improve the treatment strategy.
Victorchérouvrierhansson He is a medical student and doctoral candidate from the Department of Experimental Science at the Department of Glyph Biology at the Department of Glyph Biology. His research focuses on exploring the role of cancer in cancer. Victor works under the supervision of Professor Katrin Mani.
