The pancreatic metastases of kidney cancer are very rare and interesting. Generally, when kidney cancer spreads, it affects multiple organs, but in these uncommon cases, it will only affect pancreatic. What is even more surprising is that these metastases are usually preliminary diagnosis of kidney cancer and surprising good surgery and drug treatment results after many years, sometimes even ten years. This unusual cancer diffusion model has triggered important issues of genetic and biological factors that may explain this unique behavior.
Researchers led by Professor Franz Sellner at Emperor Franz Joseph Hospital, with Professor Eva Compérat at the University of Vienna Medical University, and Professor Martin Klimpfinger, conducted a comprehensive review of the existing research on the isolated pancreatic pancreatic pancreatic pancreatic pancreas. This work has an overview and analysis of limited research on this rare transfer form published so far. Their comments were published in the International Molecular Science Journal.
A key observation result of review is that the PBRM1 gene often changes, which is related to the better results of patients. Professor Sellner explained: “Our analysis results show that compared with other parts, genetic factors (such as higher levels of PBRM1 mutations and fewer PAB1 mutations) may lead to low aggression of pancreas.” However, they emphasized that they emphasized Because the number of cases available for research is small, these conclusions must be taken with caution.
This review also studied the wider genetic and apparent genetic factors in RCC (such as the reduction of DNA methylation in certain genes, and changes in Mic China’s activity in certain genes). These factors may spread And play a role in growth. As the author pointed out, ISPMRCC shows an independent genetic map, which is characterized by the low frequency of copies of copies related to aggressive numbers such as 9P, 14Q, and 4Q deficiency, and the genetic instability index is low. In addition, the transparent cell renal cancer’s pancreatic metastasis does not belong to the inflammatory subtype, but belongs to the vascular type subtype. This behavior confirmed that limited clinical data that produced good reactions in the treatment of vascular production without response to IT. This type of tumor is also developing as a personal chemotherapy. Doctors form a customized chemotherapy based on individual genetic/apparent genetic scholarship, which is very important for managing these unique pancreatic metastasis.
Their comments also support the “seed and soil” point of view, which believes that some cancers often spread to specific organs due to favorable conditions in these tissues. In this case, pancreas may provide a more susceptible environment for cancer cells with stable genes. Professor Celina commented: “This theory provides opinions about why pancreas is more likely to attract these metastlasia, but more research is needed to fully understand the fundamental reasons.”
Overall, the summary of Professor Sellner, Professor Compérat and Professor Klimpfinger provided valuable insights on the genetic and biological characteristics of transparent cell renal cancer separation of pancreatic metastasis. Researchers emphasized that these findings should be explained carefully, because the number of cases is still very small, and more research is needed. Their work has paved the way for future research. These studies may bring better and more personalized treatment to this rare cancer. One day may help us reduce tumor metastasis potential in treatment.
Journal reference
Sellner, F., Compérat, E. and Klimpfinger, M. “The genetic and epigenetic characteristics of transparent cell renal cell carcinoma isolated pancreatic pancreatic pancreatic pancreas”. internationality. J. Moore. science. 2023 April 16292.
About the author
Professor Franz Selner He obtained a PhD in Medicine at the University of Vienna in 1971. Emperor Hospital. In 2008, he was awarded the title of “University Professor” of the Surgery University of Vienna Medical University. He has published 145 research works, referenced 1330 times, and 2135 reads. The field includes: small intestinal adenoma-cancer sequences; epidemiological and surgical therapy for tumors and pancreatic tumors around the abdomen; epidemiology and “seeds and” seeds and seeds “And soil mechanism” controversy on the metastasis of the isolation pancreas of renal cell carcinoma.
Professor Eva Compérat It is the director of L’A’SSISTANCE PUBLIQUE-HôPITAUX de Paris pathology department of Paris, France, and consulting pathologists (EAU) for the European Urology Association to study muscle infiltration and non-muscle infiltration bladder cancer and penile cancer. She is also a member of several famous International Associations of Urology, including EAU, the International Association of Urology and Urology and Urology Pathology. She is a member of the journals such as the World of World Paths, Pathology and European Urology Magazine, etc. (4th edition) The co -author of. She is also committed to educational work in the professional field (since 2002, she has been a faculty in Pierre and Mary Hurry University in Paris), and often contributes to the education exchanges of the School of International Pathology. She is currently the Austrian Department of the Department of Pathology of Vienna Medical University.
Professor Martin Klinpiner He studied medicine at the University of Grazkar Francezen (KFU) Medical College (2004: Graz Medical University) and obtained a doctorate in 1983. From 1997 to 2020, he served as Director of the Institute of Pathmology, Kaiser Franz Josef-Spital, the Institute of Pathmology, the Academic Teaching Hospital of the Vienna Medical University. From the year until 2018, he served as the former chairman of the Austrian Clinical Pathology and Molecular Pathology Society (formerly known as the Austrian Society-the Austrian Society Austrian Branch). At present, he has been a member of the association’s board of directors since 2019 and is responsible for public relations.
