Sapio Sciences announces enhancements in chemistry, immunogenicity, GMP and molecular biology capabilities

Sapio Sciences, the science-aware™ laboratory informatics platform, today announced version 24.12, introducing new tools for chemistry, molecular biology, GMP workflows and immunogenicity. These advancements simplify laboratory operations, improve accuracy, and support the growing demands of scientific research.

Key highlights include:

• Immunogenicity Module: Automated workflows for streamlined validation and powerful data analysis.
• Improved GMP workflow: Integrated monitoring and testing capabilities reduce system load and increase accuracy.
• Enhanced chemical representation: Stereoisomer management with advanced relative stereochemistry support and refined substructure search capabilities.
• Expanded Molecular Biology Features: New capabilities for batch cloning and sequence assembly, and the introduction of the Protein Sequencer Viewer.

Kevin Cramer, founder, CEO and chief technology officer of Sapio Sciences, commented: “Sapio’s mission is to accelerate discovery by simplifying the complexity of science, and the new features in version 24.12 demonstrate our commitment to delivering advanced and intuitive capabilities that enable scientists to work faster and more confidently across complex workflows. Work.

Kevin continued: “The Sapio platform continues to evolve to meet the needs of scientists in rapidly evolving research fields. The latest updates reflect Sapio’s continued commitment to providing researchers with advanced solutions that streamline processes, improve data accuracy, and accelerate scientific discovery.

introduce Immunogenicity module

First released in October 2024, the new immunogenicity (IgX) module simplifies control mapping, supports multiple validation workflows, and is available within Sapio LIMS (Laboratory Information Management System) and ELN (Electronic Laboratory Notebook) Automate data analysis. By reducing manual work and ensuring data integrity, these capabilities enable researchers to more efficiently handle complex immunogenicity workflows while maintaining accuracy and reliability.

Enhanced functionality GMP workflow

The latest update to Sapio’s GMP (Good Manufacturing Practice) module focuses on improving monitoring and testing workflows, providing greater flexibility and accuracy. GMP workflows have been integrated into the Integrated Data View (IDV) external to ELN, reducing system load and improving material and instrument tracking capabilities.

Environmental monitoring routines have been enhanced to capture a wider range of data, including literals, true/false indicators, and numerical values. These updates streamline the overall GMP process by allowing users to add annotations and additional metadata to batch records in test configurations, receive samples, initiate test workflows, and process analytical data more efficiently.

Progress in chemical informatics

The chemistry module in Sapio LIMS and ELN now includes upgraded capabilities for managing and analyzing chemical data. These updates include enhanced relative stereochemistry support that simplifies the handling of stereoisomers during naming, identification, and registration. Stereoparsing functionality has also been added to the compound and reagent registries, allowing users to refine searches by specifying stereospecific queries or broadening the search to include all variants.

Additionally, the ability to define any number of registries to handle, for example, research compounds, chemical reagents, and/or virtually designed compounds has been added.

Expanded Molecular Biology Capabilities

Sapio continues to enhance its molecular biology toolkit with a series of new features designed to simplify sequence assembly, alignment and analysis. Batch cloning and combinatorial assembly capabilities have been added, allowing researchers to seamlessly track and compare sequence derivatives and lineages.

The introduction of the Protein Sequencer Viewer allows direct import of InterProScan data, NCBI protein accession numbers or UniProt IDs, providing researchers with greater flexibility in their analyses. In addition, protein sequences can now be translated directly together with DNA sequences, simplifying the editing and analysis of protein products.